1-{2-[(5-bromopyridin-3-yl)oxy]ethyl}-4-methyl-piperazine | 1160924-39-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-{2-[(5-bromopyridin-3-yl)oxy]ethyl}-4-methyl-piperazine
• 英文别名: 1-[2-[(5-Bromo-3-pyridinyl)oxy]ethyl]-4-methylpiperazine；1-[2-(5-bromopyridin-3-yl)oxyethyl]-4-methylpiperazine
• CAS: 1160924-39-9
• 化学式: C₁₂H₁₈BrN₃O
• 分子量: 300.198
• InChiKey: YSVIOVGYNGCDSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  28.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS
  申请人：Wyeth LLC

  公开号：EP2229377A1

  公开（公告）日：2010-09-22
• [EN] 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS<br/>[FR] 5-ALKYL/ALCÉNYL-3-CYANOPYRIDINES EN TANT QU'INHIBITEURS DE KINASE
  申请人：WYETH CORP

  公开号：WO2009076602A1

  公开（公告）日：2009-06-18

  Described herein are compounds of formula I: wherein G is and pharmaceutically acceptable salts thereof, wherein J, X, R1, R2, R11, R12' and p are as defined herein. Also provided herein are methods of making the compounds of formula I, and methods of using these compounds for inhibiting or treating a pathological condition or disorder linked to or mediated by a protein kinase in a mammal.