dimethyl tetraoctyldiglycolamide | 1332306-00-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: dimethyl tetraoctyldiglycolamide
• 英文别名: 2,2'-oxybis(N,N-dioctylpropanamide)；2-[1-(dioctylamino)-1-oxopropan-2-yl]oxy-N,N-dioctylpropanamide
• CAS: 1332306-00-9
• 化学式: C₃₈H₇₆N₂O₃
• 分子量: 609.033
• InChiKey: JDYCJJZQNIQUAE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.6
• 重原子数：
  43
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  dimethyl tetraoctyldiglycolamide 在 硝酸 作用下， 以 十二烷 为溶剂， 生成 2-羟基-N-辛基-丙酰胺 、 2-hydroxy-N,N-dioctylpropanamide 、 二正辛胺 、 N-octylacetamide 、 N-辛基丙酰胺 、 N,N-二辛基-甲酰胺 、 N,N-二辛基乙酰胺 、 N,N-dioctyl-2-oxopropanamide 、 、 、 、 、 、 、 N,N-dioctyl propionamide
  参考文献：
  名称：

  Gamma-radiolytic stability of new methylated TODGA derivatives for minor actinide recycling

  摘要：

  打开理解伽马辐射下提取配体放射裂解的大门。

  DOI：

  10.1039/c5dt02484f
• 作为产物：
  描述：

  1,1'-bis(1,1'-carboxyethyl) ether 在 草酰氯 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 生成 dimethyl tetraoctyldiglycolamide
  参考文献：
  名称：

  Synthesis and Am/Eu extraction of novel TODGA derivatives

  摘要：

  Various ligands with structural modifications of the N,N,N',N'-tetraoctyl-3-oxapentanediamide (TODGA) skeleton were synthesised in good yields. These modifications include (1) the increase in chain length from one carbon to two carbons between the central ether oxygen atom and the amide moieties, (2) the addition of substituents on the carbon between the central oxygen atom and the amide moieties on one and both sides of the central oxygen, (3) the replacement of the central oxygen by a (substituted) nitrogen atom and (4) synthesis of a rigidified glycolamide. The effect of the structural modifications on their extraction behaviours toward Am(III) and Eu(III) at various nitric acid concentrations was studied. In most of the cases, the extraction does not exceed that of TODGA in the entire acidity range of 0.001-4mol/l HNO3. The extraction behaviour of monomethyl-TODGA derivative 10a resembles that of TODGA at high nitric acid concentrations. However, at lower acidities, its D values are much lower, which is beneficial for possible back-extraction steps. The aza-tripodal ligands 18a,b show reverse extraction properties compared to TODGA as far as the pH influence is concerned: at pH 2, the DAm values are 49.9 and 3.1, the DEu values are 5.9 and 0.2, and the SAm/Eu values are 8 and 11, respectively.

  DOI：

  10.1080/10610278.2010.506553

文献信息

• Preparation of Diglycolamides via Schotten–Baumann Approach and Direct Amidation of Esters
  作者：Willem Verboom、Andrea Leoncini、Jurriaan Huskens

  DOI：10.1055/s-0035-1561495

  日期：——

  Diglycolyl chlorides, commercially available or obtained from the corresponding dicarboxylic acids, have been converted into the corresponding diamides by reaction with a wide range of amines in an organic-aqueous biphasic system (Schotten–Baumann approach) in high yields. Treatment with poly(4-styrenesulfonic acid) afforded the pure compounds. Substituted diglycolyl diesters, obtained by coupling

  通过在有机-水双相体系（Schotten-Baumann 方法）中与多种胺反应，可以将二甘醇氯化物（市售的或从相应的二羧酸获得）转化为相应的二酰胺。用聚(4-苯乙烯磺酸)处理得到纯化合物。通过偶联商业单酯获得的取代的二甘醇二酯在作为催化剂的三氯化铝存在下以良好的产率直接转化为相应的二酰胺。