1-methyl-3-(propan-2-yloxy)-1H-pyrazol-4-amine | 1354241-25-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-methyl-3-(propan-2-yloxy)-1H-pyrazol-4-amine
• 英文别名: 1-methyl-3-propan-2-yloxypyrazol-4-amine
• CAS: 1354241-25-0
• 化学式: C₇H₁₃N₃O
• 分子量: 155.2
• InChiKey: MOHHSDPEILNAAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  53.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SUBSTITUTED PYRROLO[2,3-D] PYRIMIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
  申请人：SANOFI

  公开号：EP4105218A1

  公开（公告）日：2022-12-21

  Disclosed are compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are defined herein. Also disclosed are methods of using such compounds as inhibitors of LRRK2, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating neurodegenerative diseases such as Parkinson's disease,

  公开了式 (I) 的化合物或其药学上可接受的盐，其中 R1 和 R2 在本文中定义。还公开了使用此类化合物作为 LRRK2 抑制剂的方法，以及包含此类化合物的药物组合物。这些化合物可用于治疗神经退行性疾病，如帕金森病、
• [EN] SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION<br/>[FR] PYRROLO [2,3-D] PYRIMIDINES SUBSTITUÉES, LEUR PRÉPARATION ET LEUR APPLICATION THÉRAPEUTIQUE
  申请人：[en]SANOFI

  公开号：WO2022263472A1

  公开（公告）日：2022-12-22

  Disclosed are compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are defined herein. Also disclosed are methods of using such compounds as inhibitors of LRRK2, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating neurodegenerative diseases such as Parkinson's disease.