4-(2,3,4-trifluoro-phenyl)-thiazol-2-ylamine | 881401-98-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(2,3,4-trifluoro-phenyl)-thiazol-2-ylamine
• 英文别名: 4-(2,3,4-trifluorophenyl)-1,3-thiazol-2-amine
• CAS: 881401-98-5
• 化学式: C₉H₅F₃N₂S
• 分子量: 230.213
• InChiKey: GWQIWAKNKDCLPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (4-Methoxy-benzyl)-[4-(2,3,4-trifluoro-phenyl)-thiazol-2-yl]-carbamic acid tert-butyl ester 在 四氢呋喃 作用下， 以 三氟乙酸 为溶剂， 反应 5.0h， 以yielding 171 mg (99%) of the title compound as a white solid的产率得到4-(2,3,4-trifluoro-phenyl)-thiazol-2-ylamine
  参考文献：
  名称：

  Thrombopoietin Receptor Agonists

  摘要：

  公式（I）的化合物可用作促进血小板生成和巨核细胞生成的促进剂，其中A、B、D、E、W、X、Y、Z、R1和R2如上所定义。

  公开号：

  US20080076771A1

文献信息

• FUROPYRIMIDINEDIONE DERIVATIVES AS TRPAI MODULATORS
  申请人：Chaudhari Sachin Sundarlal

  公开号：US20120178766A1

  公开（公告）日：2012-07-12

  The present invention is related to novel furopyrimidinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.

  本发明涉及新型噻吩嘧啶二酮衍生物作为TRPA（瞬时受体电位亚家族A）调节剂。特别地，本文所描述的化合物可用于治疗或预防由TRPA1（瞬时受体电位亚家族A，成员1）调节的疾病、情况和/或疾患。本文还提供了用于制备所述化合物的过程，用于其合成的中间体，其制药组合物以及用于治疗或预防由TRPA1调节的疾病、情况和/或疾患的方法。
• TROMBOPOIETIN RECEPTOR AGONISTS
  申请人：Pfizer Products Incorporated

  公开号：EP1794156A2

  公开（公告）日：2007-06-13
• FUROPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS
  申请人：Glenmark Pharmaceuticals S.A.

  公开号：EP2411395A1

  公开（公告）日：2012-02-01
• [EN] TROMBOPOIETIN RECEPTOR AGONISTS<br/>[FR] AGONISTES DU RECEPTEUR DE THROMBOPOIETINE
  申请人：PFIZER PROD INC

  公开号：WO2006033005A2

  公开（公告）日：2006-03-30

  A compound of the formula (I) useful as promoters of thrombopoiesis and megakaryocytopoiesis, wherein A, B, D, E, W, X, Y, Z, R1 and R2 are defined as above.
• [EN] FUROPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS<br/>[FR] DÉRIVÉS DE FUROPYRIMIDINEDIONE À TITRE DE MODULATEURS DE TRPA1
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2010109329A1

  公开（公告）日：2010-09-30

  The present invention is related to novel furopyrimidinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPAl (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPAl. (Formula I) (I)