4-ethoxy-3-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-(3-thiophenyl)-pyridazine | 679405-32-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-ethoxy-3-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-(3-thiophenyl)-pyridazine
• 英文别名: 4-Ethoxy-3-[[2-(6-fluoropyridin-2-yl)imidazol-1-yl]methyl]-6-thiophen-3-ylpyridazine
• CAS: 679405-32-4
• 化学式: C₁₉H₁₆FN₅OS
• 分子量: 381.433
• InChiKey: CSXMDKCAFRFWGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  94
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] DERIVES DE IMIDAZOL-1-YLMETHYL PYRIDAZINE<br/>[FR] DERIVES DE IMIDAZOL-1-YLMETHYL PYRIDAZINE
  申请人：NEUROGEN CORP

  公开号：WO2004031174A1

  公开（公告）日：2004-04-15

  The invention provides imidazol-l-ylmethyl pyridazine derivatives of the Formula (I), that bind to GABAA receptors. In the above formula, R1, R2 R3, R4, R5, R6 and Ar are defined herein. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals, and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).