(2,4-Dimethyl-1,3-dioxolane-2-yl)carboxylic acid | 6413-11-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2,4-Dimethyl-1,3-dioxolane-2-yl)carboxylic acid
• 英文别名: (l)-2,4-dimethyl-1,3-dioxolane-2-carboxylic acid；2,4-dimethyl-1,3-dioxolane-2-carboxylic acid；2,4-Dimethyl-1,3-dioxolan-2-carboxylic acid
• CAS: 6413-11-2
• 化学式: C₆H₁₀O₄
• mdl: MFCD19230104
• 分子量: 146.143
• InChiKey: NGEGIUXCWQCTOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHOD OF PRODUCING PERFLUORO(2-METHYLENE-4-METHYL-1,3-DIOXOLANE)
  申请人：TOSOH CORPORATION

  公开号：US20220002262A1

  公开（公告）日：2022-01-06

  Provided is a method of producing perfluoro(2-methylene-4-methyl-1,3-dioxolane), the method including at least following processes (1) to (3): (1) reacting at least one of perfluoro(2,4-dimethyl-2-fluoroformyl-1,3-dioxolane) and a hydrolysis product thereof with a basic aqueous solution containing one or more cations selected from the group consisting of alkali metal ions and alkaline earth metal ions and then separating a liquid containing produced perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkali metal salts or perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkaline earth metal salts by a liquid separation operation; (2) performing one or more water content reduction treatments selected from the group consisting of water evaporation and water adsorption on the liquid containing the obtained perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkali metal salts or perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkaline earth metal salts to obtain perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkali metal salts or perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkaline earth metal salts in a solution state or a solid state; and (3) causing a decarboxylation reaction in a liquid phase system with the obtained perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkali metal salts or perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkaline earth metal salts in a solution state or a solid state to produce perfluoro(2-methylene-4-methyl-1,3-dioxolane).

  提供了一种制备全氟(2-亚甲基-4-甲基-1,3-二氧杂环己烷)的方法，该方法包括至少以下步骤(1)至(3)：(1)将至少一种全氟(2,4-二甲基-2-氟甲酰基-1,3-二氧杂环己烷)及其水解产物与含有选自碱金属离子和碱土金属离子的阳离子的碱性水溶液反应，然后通过液体分离操作分离出含有产生的全氟(2,4-二甲基-1,3-二氧杂环己烷-2-基)羧酸碱金属盐或全氟(2,4-二甲基-1,3-二氧杂环己烷-2-基)羧酸碱土金属盐的液体；(2)对所得到的含有全氟(2,4-二甲基-1,3-二氧杂环己烷-2-基)羧酸碱金属盐或全氟(2,4-二甲基-1,3-二氧杂环己烷-2-基)羧酸碱土金属盐的液体进行选自水蒸发和水吸附的一种或多种水分减少处理，以获得溶液状态或固态的全氟(2,4-二甲基-1,3-二氧杂环己烷-2-基)羧酸碱金属盐或全氟(2,4-二甲基-1,3-二氧杂环己烷-2-基)羧酸碱土金属盐；以及(3)在溶液状态或固态的全氟(2,4-二甲基-1,3-二氧杂环己烷-2-基)羧酸碱金属盐或全氟(2,4-二甲基-1,3-二氧杂环己烷-2-基)羧酸碱土金属盐的存在下，在液相体系中进行脱羧反应，以产生全氟(2-亚甲基-4-甲基-1,3-二氧杂环己烷)。
• PERFLUORO(2-METHYLENE-4-METHYL-1,3-DIOXOLANE) PRODUCTION METHOD
  申请人：Tosoh Corporation

  公开号：EP3878845A1

  公开（公告）日：2021-09-15

  Provided is a method of producing perfluoro(2-methylene-4-methyl-1,3-dioxolane), the method including at least following processes (1) to (3): (1) reacting at least one of perfluoro(2,4-dimethyl-2-fluoroformyl-1,3-dioxolane) and a hydrolysis product thereof with a basic aqueous solution containing one or more cations selected from the group consisting of alkali metal ions and alkaline earth metal ions and then separating a liquid containing produced perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkali metal salts or perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkaline earth metal salts by a liquid separation operation; (2) performing one or more water content reduction treatments selected from the group consisting of water evaporation and water adsorption on the liquid containing the obtained perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkali metal salts or perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkaline earth metal salts to obtain perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkali metal salts or perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkaline earth metal salts in a solution state or a solid state; and (3) causing a decarboxylation reaction in a liquid phase system with the obtained perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkali metal salts or perfluoro(2,4-dimethyl-1,3-dioxolane-2-yl)carboxylic acid alkaline earth metal salts in a solution state or a solid state to produce perfluoro(2-methylene-4-methyl-1,3-dioxolane).

  提供了一种生产全氟(2-亚甲基-4-甲基-1,3-二氧戊环)的方法，该方法至少包括以下过程(1)至(3)： (1) 将全氟(2,4-二甲基-2-氟甲酰-1,3-二氧戊环)及其水解产物中的至少一种与含有一种或多种选自碱金属离子和碱土金属离子组成的组中的阳离子的碱性水溶液反应，然后分离出含有生成的全氟(2,4-二甲基-2-氟甲酰-1,3-二氧戊环)的液体、4-二甲基-1,3-二氧戊环-2-基)羧酸碱金属盐或全氟(2,4-二甲基-1,3-二氧戊环-2-基)羧酸碱土金属盐的液体进行液体分离操作； (2) 对含有所获得的全氟(2,4-二甲基-1,3-二氧戊环-2-基)羧酸碱金属盐或全氟(2,4-二甲基-1、全氟(2,4-二甲基-1,3-二氧戊环-2-基)羧酸碱金属盐或全氟(2,4-二甲基-1,3-二氧戊环-2-基)羧酸碱土金属盐，得到溶液状态或固体状态的全氟(2,4-二甲基-1,3-二氧戊环-2-基)羧酸碱金属盐；和 (3) 在液相体系中，使获得的全氟(2,4-二甲基-1,3-二氧戊环-2-基)羧酸碱金属盐或全氟(2,4-二甲基-1,3-二氧戊环-2-基)羧酸碱土金属盐在溶液态或固态下发生脱羧反应，生成全氟(2-亚甲基-4-甲基-1,3-二氧戊环)。
• SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING PAIN
  申请人：Bio-Pharm Solutions Co., Ltd.

  公开号：EP3079685A1

  公开（公告）日：2016-10-19
• AEROSOL-GENERATING SYSTEM COMPRISING A NOVEL DELIVERY ENHANCING COMPOUND SOURCE
  申请人：Philip Morris Products S.A.

  公开号：EP3197300A1

  公开（公告）日：2017-08-02
• [EN] SULFAMATE DERIVATIVE COMPOUNDS FOR USE IN TREATING OR ALLEVIATING PAIN<br/>[FR] COMPOSÉS DE DÉRIVÉ DE SULFAMATE À UTILISER DANS LE TRAITEMENT OU L'ATTÉNUATION DE LA DOULEUR
  申请人：BIO PHARM SOLUTIONS CO LTD

  公开号：WO2015088273A1

  公开（公告）日：2015-06-18

  The present invention relates to sulfamate derivative compounds and a composition for treating and/or alleviating pain containing the sulfamate derivative compounds or a pharmaceutically acceptable salt thereof as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition for treating or alleviating pain containing a sulfamate derivative compound and/or a pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or alleviation of pain comprising administering a sulfamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or alleviation of pain; and a use of the sulfamate derivative compound or the pharmaceutically acceptable salt thereof in treating and/or alleviating pain, are provided.