methyl ((E)-5-(4-hydroxy-2-oxo-3-((2E,4E)-10,10,10-trifluoro-2,5-dimethylocta-2,4-dienoyl)-2H-pyran-6-yl)hex-1-en-1-yl)carbamate | 1457946-14-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl ((E)-5-(4-hydroxy-2-oxo-3-((2E,4E)-10,10,10-trifluoro-2,5-dimethylocta-2,4-dienoyl)-2H-pyran-6-yl)hex-1-en-1-yl)carbamate
• 英文别名: methyl N-[(E)-5-[4-hydroxy-6-oxo-5-[(2E,4E)-8,8,8-trifluoro-2,5-dimethylocta-2,4-dienoyl]pyran-2-yl]hex-1-enyl]carbamate
• CAS: 1457946-14-3
• 化学式: C₂₃H₂₈F₃NO₆
• 分子量: 471.474
• InChiKey: KDQKMVMZGRIUHE-UNKVCTAVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] ANTIBACTERIAL AGENTS: SIDECHAIN-FLUORINATED MYXOPYRONIN DERIVATIVES<br/>[FR] AGENTS ANTIBACTÉRIENS : DÉRIVÉS DE MYXOPYRONINE À CHAÎNE LATÉRALE FLUORÉE
  申请人：UNIV RUTGERS

  公开号：WO2013142812A1

  公开（公告）日：2013-09-26

  The invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, and G are as described in the specification, as well as compositions comprising a compound of formula I, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

  本发明提供了化合物I的结构：及其药用可接受的盐，其中R1、R2、R3、R4、R5和G如说明书中所述，以及包含化合物I的组合物、制备这类化合物的方法，以及使用这类化合物的方法，例如作为细菌RNA聚合酶的抑制剂和抗菌剂。
• [EN] ANTIBACTERIAL AGENTS: O-ALKYL-DEUTERATED PYRONINS<br/>[FR] AGENTS ANTIBACTÉRIENS : PYRONINES O-ALKYL-DEUTÉRÉS
  申请人：UNIV RUTGERS

  公开号：WO2019160873A1

  公开（公告）日：2019-08-22

  The invention provides compounds of formula Ia, Ib, Ic, or Id: and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Id, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

  该发明提供了化合物Ia、Ib、Ic或Id的公式，以及其盐，其中变量如规范中所述，以及包括化合物Ia-Id的组合物，制备这些化合物的方法，以及使用这些化合物的方法，例如作为细菌RNA聚合酶的抑制剂和抗菌剂。
• ANTIBACTERIAL AGENTS: SIDECHAINFLUORINATED MYXOPYRONIN DERIVATIVES
  申请人：RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY

  公开号：US20150051275A1

  公开（公告）日：2015-02-19

  The invention provides compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 R 4 , R 5 , and G are as described in the specification, as well compositions comprising a compound of formula I, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.

  本发明提供了公式I的化合物及其药学上可接受的盐，其中R1、R2、R3、R4、R5和G如规范中所述。本发明还提供了包含公式I化合物的组合物、制备这种化合物的方法以及使用这种化合物的方法，例如作为细菌RNA聚合酶的抑制剂和抗菌剂。
• ANTIBACTERIAL AGENTS: O-ALKYL-DEUTERATED PYRONINS
  申请人：Rutgers, the State University of New Jersey

  公开号：US20210002246A1

  公开（公告）日：2021-01-07

  The invention provides compounds of formula Ia, Ib, Ic, or as well as compositions comprising a compound of formula Ia-Id, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.
• US9187446B2
  申请人：——

  公开号：US9187446B2

  公开（公告）日：2015-11-17