N-(2,4,5-trifluoro-3-(3-(3-(hydroxymethyl)morpholinyl)quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide | 1425486-05-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(2,4,5-trifluoro-3-(3-(3-(hydroxymethyl)morpholinyl)quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide
• 英文别名: N-(2,4,5-trifluoro-3-(3-(3-(hydroxymethyl)morpholino)quinoxaline-6-carbonyl)phenyl)propane-1-sulfonamide；N-(2,4,5-Trifluoro-3-(3-(3-(hydroxymethyl)morpholino)quinoxalin-6-carbonyl)phenyl)-propan-1-sulfonamide；N-[2,4,5-trifluoro-3-[3-[3-(hydroxymethyl)morpholin-4-yl]quinoxaline-6-carbonyl]phenyl]propane-1-sulfonamide
• CAS: 1425486-05-0
• 化学式: C₂₃H₂₃F₃N₄O₅S
• 分子量: 524.521
• InChiKey: GBVXRBYQCDGAOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• Certain Chemical Entities, Compositions, and Methods
  申请人：Zhu Yong-Liang

  公开号：US20130053384A1

  公开（公告）日：2013-02-28

  Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are described.

  描述了一种激酶抑制剂、制药组合物和使用这些化学实体的方法，例如用于治疗癌症。
• Benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions thereof, and their use in methods for treating cancer
  申请人：NeuPharma, Inc.

  公开号：US10137125B2

  公开（公告）日：2018-11-27

  Benzenesulfonamide derivatives of quinoxaline that are kinase inhibitors, pharmaceutical compositions and methods of using these derivatives, e.g., for treatment of cancer are described.

  描述了作为激酶抑制剂的喹喔啉的苯磺酰胺衍生物、药物组合物和使用这些衍生物（例如用于治疗癌症）的方法。
• CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
  申请人：Neupharma, Inc.

  公开号：EP2747767A1

  公开（公告）日：2014-07-02
• BENZENESULFONAMIDE DERIVATIVES OF QUINOXALINE, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN METHODS FOR TREATING CANCER
  申请人：NEUPHARMA, INC.

  公开号：US20160303118A1

  公开（公告）日：2016-10-20

  Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are described.
• US9295671B2
  申请人：——

  公开号：US9295671B2

  公开（公告）日：2016-03-29