4-(2-chloro-4-fluorophenyl)-1-methyl-1H-pyrazole-5-amine | 1343730-42-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(2-chloro-4-fluorophenyl)-1-methyl-1H-pyrazole-5-amine
• 英文别名: 4-(2-chloro-4-fluorophenyl)-1-methyl-1H-pyrazol-5-amine；4-(2-chloro-4-fluorophenyl)-2-methylpyrazol-3-amine
• CAS: 1343730-42-6
• 化学式: C₁₀H₉ClFN₃
• 分子量: 225.653
• InChiKey: AFENNFPGSNUYKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-氨基-4-溴-2-甲基吡唑 、 2-氯-4-氟苯硼酸 在 sodium carbonate 、 四(三苯基膦)钯 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.17h， 以38%的产率得到4-(2-chloro-4-fluorophenyl)-1-methyl-1H-pyrazole-5-amine
  参考文献：
  名称：

  [EN] PYRAZOLE, ISOTHIAZOLE AND ISOXAZOLE DERIVATIVES USEFUL AS AGRICULTURAL FUNGICIDES
  [FR] DÉRIVÉS DE PYRAZOLE, D'ISOTHIAZOLE ET D'ISOXAZOLE UTILES EN TANT QUE FONGICIDES AGRICOLES

  摘要：

  本发明涉及用作杀菌剂的取代吡唑、异噁唑和异噻唑化合物，适用于农业领域。

  公开号：

  WO2019020981A1

文献信息

• [EN] FUNGICIDAL PYRAZOLES<br/>[FR] PYRAZOLES FONGICIDES
  申请人：DU PONT

  公开号：WO2013126283A1

  公开（公告）日：2013-08-29

  Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein Q1is a phenyl ring, naphthalenyl ring system, a 5- to 6-membered fully unsaturated heterocyclic ring or an 8- to 10-membered heteroaromatic bicyclic ring system, each as described with optional substituents as defined in the disclosure; Q2 is a phenyl ring, a naphthalenyl ring system, a 4-, 5- or 6-membered saturated, partially unsaturated or fully unsaturated heterocyclic ring, or an 8- to 10-membered heteroaromatic bicyclic ring system, each as described with optional substituents as defined in the disclosure; X is O, NR4 or CR15R16; R2 is H, C2-C3 alkenyl or C2-C3 alkynyl; and R1, R1a, R4, R15 and R16 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.

  公开了Formula 1的化合物，包括所有的几何和立体异构体，N-氧化物以及其盐，其中Q1是苯环，萘环系统，一个5-至6-成员完全不饱和的杂环环或一个8-至10-成员的杂芳双环环系统，每个如披露中定义的可选取代基；Q2是苯环，一个萘环系统，一个4-、5-或6-成员饱和、部分不饱和或完全不饱和的杂环环，或一个8-至10-成员的杂芳双环环系统，每个如披露中定义的可选取代基；X是O，NR4或CR15R16；R2是H，C2-C3烯基或C2-C3炔基；R1、R1a、R4、R15和R16如披露中定义。还公开了含有Formula 1的化合物的组合物以及用于控制由真菌病原体引起的植物疾病的方法，包括施用本发明的化合物或组合物的有效量。
• FUNGICIDAL HETEROCYCLIC CARBOXAMIDES
  申请人：E I DU PONT DE NEMOURS AND COMPANY

  公开号：US20140005231A1

  公开（公告）日：2014-01-02

  Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein L is —C(R 12a )R 12b —C(R 13a )R 13b —, wherein the carbon atom bonded to R 12a and R 12b is also bonded to the carboxamide nitrogen atom in Formula 1; or 1,2-phenylene optionally substituted with up to 4 substituents independently selected from halogen and C 1 -C 2 alkyl; and A, Z, R 1 , R 2 , n, G and Q are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention. Also disclosed are methods for controlling a phytophagous nematode comprising contacting the nematode or its environment with a nematocidally effective amount of a compound of Formula 1 wherein L is —C(R 12a )R 12b —C(R 13a )R 13b ; and A, Z, R 1 , R 2 , n, G and Q are as defined in the disclosure.

  本发明涉及公式1的化合物，包括所有立体异构体、N-氧化物和其盐，其中L为—C(R12a)R12b—C(R13a)R13b—，其中与R12a和R12b相结合的碳原子还与公式1中的羧酰胺氮原子相结合；或者是1,2-苯基，可选地取代最多4个卤素和C1-C2烷基基团；A、Z、R1、R2、n、G和Q如本公开中所定义。本发明还涉及含有公式1化合物的组合物以及应用本发明的化合物或组合物的有效量来控制由真菌病原体引起的植物病害的方法。本发明还涉及一种用公式1化合物来控制植物寄生线虫的方法，其中L为—C(R12a)R12b—C(R13a)R13b；A、Z、R1、R2、n、G和Q如本公开中所定义，与线虫或其环境接触的线虫杀灭剂有效量。
• [EN] PYRAZOLE, ISOTHIAZOLE AND ISOXAZOLE DERIVATIVES USEFUL AS AGRICULTURAL FUNGICIDES<br/>[FR] DÉRIVÉS DE PYRAZOLE, D'ISOTHIAZOLE ET D'ISOXAZOLE UTILES EN TANT QUE FONGICIDES AGRICOLES
  申请人：REDAG CROP PROT LTD

  公开号：WO2019020981A1

  公开（公告）日：2019-01-31

  The present invention relates to substituted pyrazole, isoxazole andisothiazole compounds which are of use in the field of agriculture as fungicides.

  本发明涉及用作杀菌剂的取代吡唑、异噁唑和异噻唑化合物，适用于农业领域。