Sodium 2-amino-2-deoxy-6-O-sulfonato-D-glucose | 481649-94-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Sodium 2-amino-2-deoxy-6-O-sulfonato-D-glucose
• 英文别名: sodium;[(2R,3S,4R,5R)-5-amino-2,3,4-trihydroxy-6-oxohexyl] sulfate
• CAS: 481649-94-9
• 化学式: C6H12NNaO8S
• 分子量: 281.22
• InChiKey: GFMIDPTUSRZTLR-BTVCFUMJSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -6.92
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  179
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• Composition and method for treatment and prevention of traumatic synovitis and damage to articular cartilage
  申请人：——

  公开号：US20040092479A1

  公开（公告）日：2004-05-13

  The invention provides compositions useful for the treatment and/or prevention of damage to diarthrodial (synovial) joints and, in particular, traumatic synovitis, inflammation of the synovial membrane, and damage to the articular cartilage of the joint. Specifically, provided are compositions specially formulated for intra-articular and/or parenteral use in the treatment and/or prevention of traumaticsynovitis and/or damage to articular cartilage. Compositions adapted specifically for post surgical joint lavage or treatment and/or prevention of inflammatory arthritis, osteoarthritis (OA) and/or degenerative joint disease (DJD) are also provided. Compositions adapted for intra-articular and/or systemic administration comprised of therapeutic amounts of: chondroitin sulfate; N-acetyl D-glucosamine; and hyaluronan (hyaluronic acid) are provided.

  本发明提供了用于治疗和/或预防二关节（滑膜）损伤，特别是创伤性滑膜炎、滑膜炎症和关节软骨损伤的组合物。具体来说，本发明提供了专门配制的组合物，用于关节内和（或）肠外治疗和（或）预防创伤性滑膜炎和（或）关节软骨损伤。还提供了专门用于手术后关节灌洗或治疗和/或预防炎症性关节炎、骨关节炎（OA）和/或退行性关节病（DJD）的组合物。本发明还提供了适用于关节内和/或全身给药的组合物，其中包含治疗量的硫酸软骨素、N-乙酰 D-氨基葡萄糖和透明质酸（玻尿酸）。
• Composition comprising CS
  申请人：Nocelli Luca

  公开号：US20050142194A1

  公开（公告）日：2005-06-30

  The present invention concerns new chondroitin sulfate compositions with a twofold therapeutic action. The new compositions of the invention are characterised by a high patient compliance, being extremely useful for prolonged therapy. To achieve these aims, the new compositions contain primary and secondary structuring agents, as well as defined amounts of water for pre-dissolving the active principle contained therein.

  本发明涉及具有双重治疗作用的新型硫酸软骨素组合物。本发明的新组合物具有患者依从性高的特点，非常适用于长期治疗。为达到上述目的，新组合物含有一级和二级结构剂，以及一定量的水，用于预先溶解其中所含的活性成分。
• CRYSTALLINE GLUCOSAMINE SULPHATE METAL SALTS AND PROCESSES FOR PREPARING THE SAME
  申请人：Nicholas Piramal India Limited

  公开号：EP1347986B1

  公开（公告）日：2005-04-13
• EP1347986A4
  申请人：——

  公开号：EP1347986A4

  公开（公告）日：2004-01-21
• COMPOSITIONS OF ORALLY ADMINISTERED NUTRITIONAL SUPPLEMENTS TO REPAIR ARTICULAR CARTILAGE
  申请人：Madere, Shawn Paul

  公开号：EP1408988A1

  公开（公告）日：2004-04-21