methyl (2R,3S)-2,3-dimethyl-4-oxo-4-phenylbutanoate | 946008-06-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl (2R,3S)-2,3-dimethyl-4-oxo-4-phenylbutanoate
• CAS: 946008-06-6
• 化学式: C₁₃H₁₆O₃
• 分子量: 220.268
• InChiKey: OFUADMISSMIRMU-VHSXEESVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  三甲基硅烷化重氮甲烷 、 (2R,3S)-2,3-dimethyl-4-oxo-4-phenylbutyric acid 以 甲醇 、 乙醚 、 苯 为溶剂， 生成 methyl (2R,3S)-2,3-dimethyl-4-oxo-4-phenylbutanoate
  参考文献：
  名称：

  Ligand differentiated complementary Rh-catalyst systems for the enantioselective desymmetrization of meso-cyclic anhydrides

  摘要：

  Two distinct systems for the rhodium-catalyzed enantioselective desymmetrization of meso-cyclic anhydrides have been developed. Each system has been optimized and are compatible with the use of in situ prepared organozinc reagents. Rhodium/PHOX species efficiently catalyze the addition of alkyi nucleophiles to glutaric anhydrides, while system is effective in the enantioselective arylation of succinic and glutaric anhydrides. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.10.075

文献信息

• Ligand differentiated complementary Rh-catalyst systems for the enantioselective desymmetrization of meso-cyclic anhydrides
  作者：Jeffrey B. Johnson、Matthew J. Cook、Tomislav Rovis

  DOI：10.1016/j.tet.2008.10.075

  日期：2009.4

  Two distinct systems for the rhodium-catalyzed enantioselective desymmetrization of meso-cyclic anhydrides have been developed. Each system has been optimized and are compatible with the use of in situ prepared organozinc reagents. Rhodium/PHOX species efficiently catalyze the addition of alkyi nucleophiles to glutaric anhydrides, while system is effective in the enantioselective arylation of succinic and glutaric anhydrides. (C) 2008 Elsevier Ltd. All rights reserved.