2'-O-Methylguanosine 5'-(α-thiotriphosphate) | 847648-38-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2'-O-Methylguanosine 5'-(α-thiotriphosphate)
• 英文别名: alpha-Thio-((2R,3R,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-hydroxy-4-methoxytetrahydrofuran-2-yl)methyl triphosphate；[[(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxy-4-methoxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl] phosphono hydrogen phosphate
• CAS: 847648-38-8
• 化学式: C₁₁H₁₈N₅O₁₃P₃S
• 分子量: 553.277
• InChiKey: PTDOTKSKFQMXQJ-NRSRKINISA-N

物化性质

• 沸点：
  931.1±75.0 °C(Predicted)
• 密度：
  2.45±0.1 g/cm3(Predicted)

反应信息

• 作为产物：
  描述：

  N'-(9-{(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-methoxy-tetrahydro-furan-2-yl}-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethyl-formamidine 生成 2'-O-Methylguanosine 5'-(α-thiotriphosphate)
  参考文献：
  名称：

  Novel solid phase synthesis of 2'-o-methylribonucleoside 5'-triphosphates and their α-thio analogues

  摘要：

  Simple, versatile and convenient syntheses of 2'-0-methyl-ribonucleoside 5'-triphosphates have been accomplished on controlled pore glass (CPG) in good yield (>60%) using 2-chloro-4H-1,3,2-benzodioxaphosphorin-4-one (salicyl phosphorochloridite). Moderate yields were obtained for the corresponding alpha-thiotri-phosphates.

  DOI：

  10.1016/s0040-4039(00)92072-0