N'-[(4-nitrophenyl-3-phenylthiazol-2(3H)-ylidene)]-2-[(1-phenyl-1H-tetrazol-5-yl)thio]acetohydrazide | 1574548-83-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N'-[(4-nitrophenyl-3-phenylthiazol-2(3H)-ylidene)]-2-[(1-phenyl-1H-tetrazol-5-yl)thio]acetohydrazide
• CAS: 1574548-83-6
• 化学式: C₂₄H₁₈N₈O₃S₂
• 分子量: 530.591
• InChiKey: BHTUVIFCVADDRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.81
• 重原子数：
  37.0
• 可旋转键数：
  8.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  133.13
• 氢给体数：
  1.0
• 氢受体数：
  11.0

反应信息

• 作为产物：
  描述：

  ethyl 2-(1-phenyl-1H-tetrazol-5-ylthio)acetate 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 16.0h， 生成 N'-[(4-nitrophenyl-3-phenylthiazol-2(3H)-ylidene)]-2-[(1-phenyl-1H-tetrazol-5-yl)thio]acetohydrazide
  参考文献：
  名称：

  Synthesis and biological evaluation of thiazoline derivatives as new antimicrobial and anticancer agents

  摘要：

  N'-(3,4-Diarylthiazol-2(3H)-ylidene)-2-(arylthio)acetohydrazides were synthesized and evaluated for their antimicrobial activity and cytotoxicity against NIH/3T3 cells. Compound 22 bearing 1-phenyl-1H-tetrazole and p-chlorophenyl moieties was found to be the most promising antibacterial agent against Pseudomonas aeruginosa, whereas compound 23 bearing 1-phenyl-1H-tetrazole and p-bromophenyl moieties was the most promising antifungal agent against Candida albicans. The most effective derivatives were also evaluated for their cytotoxicity against C6 glioma cells. The results indicated that compound 17 bearing 1-phenyl-1H-tetrazole and nonsubstituted phenyl moieties (IC50 = 8.3 +/- 2.6 mu g/mL) was more effective than cisplatin (IC50 = 13.7 +/- 1.2 mu g/mL) against C6 glioma cells. Compound 17 also exhibited DNA synthesis inhibitory activity on C6 cells. Furthermore, compound 17 showed low toxicity to NIH/3T3 cells (IC50 = 416.7 +/- 28.9 mu g/mL). (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.12.060