H-Dap-Asp-Cys-OH | 1452144-89-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Dap-Asp-Cys-OH
• 英文别名: (3S)-4-[[(1R)-1-carboxy-2-sulfanylethyl]amino]-3-[[(2S)-2,3-diaminopropanoyl]amino]-4-oxobutanoic acid
• CAS: 1452144-89-6
• 化学式: C₁₀H₁₈N₄O₆S
• 分子量: 322.342
• InChiKey: BBKNJBMGATZTJS-ZLUOBGJFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  186
• 氢给体数：
  7
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  L-2,3-二氨基丙酸 、 Fmoc-L-天冬氨酸 beta-叔丁酯 、 Fmoc-S-三苯甲基-L-半胱氨酸 在 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 哌啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 H-Dap-Asp-Cys-OH
  参考文献：
  名称：

  [EN] CHOLECYSTOKININ B RECEPTOR TARGETING FOR IMAGING AND THERAPY
  [FR] CIBLAGE DU RÉCEPTEUR DE LA CHOLÉCYSTOKININE DE TYPE B POUR IMAGERIE ET THÉRAPIE

  摘要：

  本文描述了共轭物，其中CCK2R靶向配体通过连接剂连接到活性基团，如治疗剂或成像剂。这些共轭物可用于癌症的检测、诊断、成像和治疗。

  公开号：

  WO2013126797A1

文献信息

• [EN] CARBONIC ANHYDRASE IX TARGETING AGENTS AND METHODS<br/>[FR] AGENTS ET PROCÉDÉS CIBLANT L'ANHYDRASE CARBONIQUE IX
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：WO2017161170A1

  公开（公告）日：2017-09-21

  The present disclosure relates to compositions and methods of carbonic anhydrase IX inhibitors. The present disclosure also relates to targeting conjugates of carbonic anhydrase IX inhibitors. The present disclosure also relates to the use of targeting conjugates of carbonic anhydrase IX inhibitors in SPECT imaging methods.

  本公开涉及碳酸酐酶IX抑制剂的组合物和方法。本公开还涉及碳酸酐酶IX抑制剂的靶向共轭物。本公开还涉及在单光子发射计算断层扫描成像方法中使用碳酸酐酶IX抑制剂的靶向共轭物。
• Luteinizing hormone-releasing hormone receptor (LHRH-R) conjugates and uses thereof
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：US10821188B2

  公开（公告）日：2020-11-03

  The present teachings relate generally to conjugates and methods for imaging a tumor microenvironment in a patient, and to conjugates and methods for treating LHRH-R expressing cancer in a patient. The present teachings relate generally to method of making conjugates comprising an LHRH-R antagonist.

  本教导一般涉及用于患者肿瘤微环境成像的共轭物和方法，以及用于治疗患者LHRH-R表达癌症的共轭物和方法。本教导一般涉及包含LHRH-R拮抗剂的共轭物的制造方法。
• DESIGN AND DEVELOPMENT OF NEUROKININ-1 RECEPTOR-BINDING AGENT DELIVERY CONJUGATES
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：US20170216465A1

  公开（公告）日：2017-08-03

  Neurokinin-1 (NK-1) receptor-binding agent delivery conjugates, compositions comprising NK-1 receptor-binding agent delivery conjugates, and methods for making and administering NK-1 receptor-binding agent delivery conjugates are provided. A conjugate may include an NK-1 receptor-binding moiety, a linker group containing at least one linker selected from the group of a releasable linker and a spacer linker, and an active agent linked to the linker group. The active agent may be selected from the group of fluorophore-containing compounds, radionuclide-containing compounds, and therapeutic agents for treatment of tumor cells characterized by over-expression of the NK-1 receptor.
• CARBONIC ANHYDRASE IX TARGETING AGENTS AND METHODS
  申请人：Purdue Research Foundation

  公开号：US20190083663A1

  公开（公告）日：2019-03-21

  The present disclosure relates to compositions and methods of carbonic anhydrase IX inhibitors. The present disclosure also relates to targeting conjugates of carbonic anhydrase IX inhibitors. The present disclosure also relates to the use of targeting conjugates of carbonic anhydrase IX inhibitors in SPECT imaging methods.
• LUTEINIZING HORMONE-RELEASING HORMONE RECEPTOR (LHRH-R) CONJUGATES AND USES THEREOF
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：US20210290767A1

  公开（公告）日：2021-09-23

  The present teachings relate generally to conjugates and methods for imaging a tumor microenvironment in a patient, and to conjugates and methods for treating LHRH-R expressing cancer in a patient. The present teachings relate generally to method of making conjugates comprising an LHRH-R antagonist.