((2S,3S,4R,5S,6S)-3,4,5-Trihydroxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-phosphonic acid; compound with triethyl-amine | 145933-75-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ((2S,3S,4R,5S,6S)-3,4,5-Trihydroxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-phosphonic acid; compound with triethyl-amine
• CAS: 145933-75-1
• 化学式: 2C₆H₁₅N*C₇H₁₅O₇P
• 分子量: 444.549
• InChiKey: VCPQOVQVQSAKRH-ASDVICBBSA-N

反应信息

• 作为反应物：
  描述：

  ((2S,3S,4R,5S,6S)-3,4,5-Trihydroxy-6-methyl-tetrahydro-pyran-2-ylmethyl)-phosphonic acid; compound with triethyl-amine 、 dicyclohexylcarboxamidinium salt of guanosine 5'-monophosphomorpholidate 以 吡啶 为溶剂， 反应 168.0h， 生成
  参考文献：
  名称：

  Synthesis of C-fucopyranosyl analogs of GDP-L-fucose as inhibitors of fucosyltransferases

  摘要：

  The syntheses of the C-fucopyranosyl analogs of GDP-L-fucose 2 - 5 as potential inhibitors of fucosyltransferases are reported. The synthetic routes are based on the C-glycosidation of tetra-O-acetyl-alpha-L-fucopyranose 6 under conditions that provided either beta- or alpha- C-fucosides with high stereoselectivity. Coupling to GMP was effected by Khorana's phosphomorpholidate method.

  DOI：

  10.1016/s0040-4039(00)60893-6