p-Toluolsulfonyl-L-arginin-aethylester | 7345-28-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: p-Toluolsulfonyl-L-arginin-aethylester
• 英文别名: α-N-Tosyl-L-argininaethylester；Tos-Arg-OEt；p-Toluenesulfonyl-l-arginin ethyl ester；ethyl (2S)-5-(diaminomethylideneamino)-2-[(4-methylphenyl)sulfonylamino]pentanoate
• CAS: 7345-28-0
• 化学式: C₁₅H₂₄N₄O₄S
• 分子量: 356.446
• InChiKey: RJLCUUMGNUDPPI-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  145
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Cycloalkylcarbonylamino Acid Ester Derivative and Process for Producing The Same
  申请人：Kobayashi Nobuo

  公开号：US20090137799A1

  公开（公告）日：2009-05-28

  Cycloalkylcarbonylamino acid ester derivatives, which are raw material intermediates for a novel cycloalkane carboxamide derivative having an action that selectively inhibits cathepsin K, and a production process thereof, are provided. A cycloalkylcarbonylamino acid ester derivative represented by formula (I), or a pharmaceutically acceptable salt thereof: (wherein, R 1 and R 2 represent alkyl groups, alkenyl groups, alkynyl groups, aromatic hydrocarbon groups, heterocyclic groups, etc., R 8 represents an alkyl group having 1 to 6 carbon atoms, and ring A represents a cyclic alkylidene group having 5, 6 or 7 carbon atoms).

  环烷基羰基氨基酸酯衍生物是一种新型环烷烃羧酰胺衍生物的原料中间体，具有选择性抑制卡特普辛K的作用，提供其生产工艺。 表示为式（I）的环烷基羰基氨基酸酯衍生物，或其药学上可接受的盐： （其中，R1和R2代表烷基、烯基、炔基、芳香烃基、杂环基等，R8代表具有1至6个碳原子的烷基，环A代表具有5、6或7个碳原子的环烷基亚基）。
• Cycloalkane Carboxamide Derivatives and Production Process of Same
  申请人：Kobayashi Nobuo

  公开号：US20090156805A1

  公开（公告）日：2009-06-18

  Novel cycloalkane carboxamide derivatives having an action that selectively inhibits cathepsin K, and a production process thereof, are provided. A cycloalkane carboxamide derivative represented by the following general formula (I), or a pharmaceutically acceptable salt thereof: (wherein R 1 and R 2 represent (substituted) alkyl groups, (substituted) alkenyl groups, (substituted) alkynyl groups, (substituted) aromatic hydrocarbon groups or (substituted) heterocyclic groups, ring A represents an alkylidene group having 5 to 7 carbon atoms, and ring B represents a formyl group or a hydroxymethyl group).

  本发明提供了一种具有选择性抑制蛋白酶K的作用的新型环烷基羧酰胺衍生物及其生产工艺。其中，所述环烷基羧酰胺衍生物由下述通式（I）表示，或其药学上可接受的盐所表示（其中，R1和R2代表（取代）烷基、（取代）烯基、（取代）炔基、（取代）芳香族碳氢基或（取代）杂环基，环A表示具有5至7个碳原子的烷基亚基，环B表示甲酰基或羟甲基）。
• CYCLOALKANECARBOXAMIDE DERIVATIVE AND METHOD FOR PRODUCING SAME
  申请人：SEIKAGAKU CORPORATION

  公开号：EP1972615A1

  公开（公告）日：2008-09-24

  Novel cycloalkane carboxamide derivatives having an action that selectively inhibits cathepsin K, and a production process thereof, are provided. A cycloalkane carboxamide derivative represented by the following general formula (I), or a pharmaceutically acceptable salt thereof: (wherein R1 and R2 represent (substituted) alkyl groups, (substituted) alkenyl groups, (substituted) alkynyl groups, (substituted) aromatic hydrocarbon groups or (substituted) heterocyclic groups, ring A represents an alkylidene group having 5 to 7 carbon atoms, and ring B represents a formyl group or a hydroxymethyl group).

  本发明提供了具有选择性抑制 cathepsin K 作用的新型环烷烃羧酰胺衍生物及其生产工艺。 由以下通式(I)代表的环烷烃羧酰胺衍生物或其药学上可接受的盐： (其中R1和R2代表（取代的）烷基、（取代的）烯基、（取代的）炔基、（取代的）芳香烃基团或（取代的）杂环基团，环A代表具有5至7个碳原子的亚烷基，环B代表甲酰基或羟甲基）。
• CYCLOALKYLCARBONYLAMINO ACID ESTER DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
  申请人：SEIKAGAKU CORPORATION

  公开号：EP2036920A1

  公开（公告）日：2009-03-18

  Cycloalkylcarbonylamino acid ester derivatives, which are raw material intermediates for a novel cycloalkane carboxamide derivative having an action that selectively inhibits cathepsin K, and a production process thereof, are provided. A cycloalkylcarbonylamino acid ester derivative represented by formula (I), or a pharmaceutically acceptable salt thereof: (wherein, R1 and R2 represent alkyl groups, alkenyl groups, alkynyl groups, aromatic hydrocarbon groups, heterocyclic groups, etc., R8 represents an alkyl group having 1 to 6 carbon atoms, and ring A represents a cyclic alkylidene group having 5, 6 or 7 carbon atoms).

  本发明提供了环烷基羰基氨基酸酯衍生物，它是一种新型环烷羧酰胺衍生物的原料中间体，该衍生物具有选择性抑制凝血酶 K 的作用，并提供了其生产工艺。 一种由式（I）代表的环烷基羰基氨基甲酸酯衍生物，或其药学上可接受的盐： (其中，R1 和 R2 代表烷基、烯基、炔基、芳香烃基、杂环基等，R8 代表具有 1 至 6 个碳原子的烷基，环 A 代表具有 5、6 或 7 个碳原子的环亚烷基）。
• Bowman-Birk protease Inhibitor (BBI) binding peptides, and uses thereof in the separation, detection or purification of BBI.
  申请人：University College Dublin National University Of Ireland, Dublin

  公开号：EP2604624A1

  公开（公告）日：2013-06-19

  Peptide probes against the soybean Bowman-Birk Inhibitor (BBI) are described. Also described are uses of the peptide probes of the invention for detecting, separating, or purifying BBI from complex protein mixtures such as soy whey, and as an affinity separation matrix comprising a peptide probe of the invention immobilised to a support such as a magnetic bead.

  本发明描述了针对大豆鲍曼-伯克抑制物（BBI）的肽探针。还描述了本发明肽探针在检测、分离或纯化复杂蛋白质混合物（如大豆乳清）中的 BBI 方面的用途，以及作为亲和分离基质的用途，该基质包括固定在磁珠等支持物上的本发明肽探针。