[(R)-2-(5-(pyridin-3-yl)oxy-7-(tetrahydropyran-4-yl)amino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-acetic acid | 1120343-02-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [(R)-2-(5-(pyridin-3-yl)oxy-7-(tetrahydropyran-4-yl)amino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-acetic acid
• 英文别名: 2-[(4R)-2-[7-(oxan-4-ylamino)-5-pyridin-3-yloxy-1H-indol-2-yl]-4,5-dihydro-1,3-thiazol-4-yl]acetic acid
• CAS: 1120343-02-3
• 化学式: C₂₃H₂₄N₄O₄S
• 分子量: 452.534
• InChiKey: JRPUXGVBCFOJNE-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  134
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS
  申请人：Kim Soon Ha

  公开号：US20100210647A1

  公开（公告）日：2010-08-19

  The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

  本发明涉及新的吲哚化合物，其药学上可接受的盐或异构体，用于预防或治疗细胞坏死和坏死相关疾病。本发明还涉及一种预防或治疗细胞坏死和坏死相关疾病的方法和组合物，该组合物包括所述吲哚化合物作为活性成分。
• [EN] INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS<br/>[FR] COMPOSÉS D'INDOLE EN TANT QU'INHIBITEURS DE NÉCROSE CELLULAIRE
  申请人：LG LIFE SCIENCES LTD

  公开号：WO2009025477A1

  公开（公告）日：2009-02-26

  The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.

  本发明涉及新的吲哚化合物、药学上可接受的盐或其异构体，用于预防或治疗细胞坏死和坏死相关疾病。本发明还涉及一种预防或治疗细胞坏死和坏死相关疾病的方法和组合物，其包括所述吲哚化合物作为活性成分。
• GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT
  申请人：Kim Soon Ha

  公开号：US20100267708A1

  公开（公告）日：2010-10-21

  The present invention relates to new compounds of formula (1) exhibiting excellent activity for glucokinase, and pharmaceutical compositions comprising the same as an active ingredient.

  本发明涉及公式（1）的新化合物，表现出对葡萄糖激酶的优异活性，并且包括该化合物作为活性成分的药物组合物。
• US8222414B2
  申请人：——

  公开号：US8222414B2

  公开（公告）日：2012-07-17
• US8309586B2
  申请人：——

  公开号：US8309586B2

  公开（公告）日：2012-11-13