1,2,4,5-tetradeoxy-1-(3,5-difluorophenyl)-2-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-5-[(3-ethylbenzyl)amino]-D-erythro-pentitol | 506432-03-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2,4,5-tetradeoxy-1-(3,5-difluorophenyl)-2-({3-[(dipropylamino)carbonyl]-5-methylbenzoyl}amino)-5-[(3-ethylbenzyl)amino]-D-erythro-pentitol
• 英文别名: 1-N-[(2S,3R)-1-(3,5-difluorophenyl)-5-[(3-ethylphenyl)methylamino]-3-hydroxypentan-2-yl]-5-methyl-3-N,3-N-dipropylbenzene-1,3-dicarboxamide
• CAS: 506432-03-7
• 化学式: C₃₅H₄₅F₂N₃O₃
• 分子量: 593.757
• InChiKey: COCWEIBWWJKYMQ-JHOUSYSJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  43
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  81.7
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Hydroxypropylamines
  申请人：——

  公开号：US20030125365A1

  公开（公告）日：2003-07-03

  Disclosed are compounds of formula I: 1 and the pharmaceutically acceptable salts thereof wherein the variables R N , R 1 , R 2 , R 3 , R P and R C are defined herein. These compounds are useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

  公开了式 I 的化合物： 1 及其药学上可接受的盐类，其中变量 R N , R 1 , R 2 , R 3 , R P 和 R C 的定义。这些化合物可用于治疗阿尔茨海默病和其他类似疾病。这些化合物包括β-分泌酶的抑制剂，可用于治疗阿尔茨海默病和其他以哺乳动物体内A-β肽沉积为特征的疾病。本发明的化合物可用于药物组合物和治疗方法，以减少 A beta 肽的形成。
• Hydroxypropylaimines
  申请人：Fisher F. Jed

  公开号：US20070299117A1

  公开（公告）日：2007-12-27

  Disclosed are compounds of formula I: and the pharmaceutically acceptable salts thereof wherein the variables R N , R 1 , R 2 , R 3 , R p and R C are defined herein. These compounds are useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
• US7244755B2
  申请人：——

  公开号：US7244755B2

  公开（公告）日：2007-07-17