N-[4-chloro-3-(1,5-dimethyl-1H-imidazol-2-yl)phenyl]-6-phenoxypyridine-3-carboxamide | 1128191-32-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[4-chloro-3-(1,5-dimethyl-1H-imidazol-2-yl)phenyl]-6-phenoxypyridine-3-carboxamide
• 英文别名: N-[4-chloro-3-(1,5-dimethylimidazol-2-yl)phenyl]-6-phenoxypyridine-3-carboxamide
• CAS: 1128191-32-1
• 化学式: C₂₃H₁₉ClN₄O₂
• 分子量: 418.882
• InChiKey: RCYMSYQMPQRKSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  69
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF-975<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：ASTRAZENECA AB

  公开号：WO2009030952A2

  公开（公告）日：2009-03-12

  The present disclosure relates to heterocyclic amide compounds, which are useful for inhibiting the Hedgehog pathway, and their use in treating a disease or medical condition mediated alone or in part by Hedgehog pathway inhibition. Also disclosed are methods for manufacture of these compounds, pharmaceutical compositions including these compounds, and use of these compounds in the manufacture of medicaments for treating such diseases and medical conditions in a subject. (I)