4-C-hydroxymethyl-1,2-O-isopropylidene-β-L-threo-pentofuranose | 55797-65-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-C-hydroxymethyl-1,2-O-isopropylidene-β-L-threo-pentofuranose
• 英文别名: (3aR,6S,6aR)-5,5-bis(hydroxymethyl)-2,2-dimethyl-6,6a-dihydro-3aH-furo[2,3-d][1,3]dioxol-6-ol
• CAS: 55797-65-4
• 化学式: C₉H₁₆O₆
• 分子量: 220.222
• InChiKey: IQMIEGQNCDSYBA-VQVTYTSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  88.4
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• 6-Disubstituted Or Unsaturated Bicyclic Nucleic Acid Analogs
  申请人：Seth Punit P.

  公开号：US20110053881A1

  公开（公告）日：2011-03-03

  The present disclosure describes 6-disubstituted bicyclic nucleosides, oligomeric compounds prepared therefrom and methods of using the oligomeric compounds. More particularly, the 6-disubstituted bicyclic nucleosides each comprise a 2′-O—C(Ri)(R2)-4′ or 2′-O—C=(R3)(R.4)-4′ bridge wherein each R is, independently a substituent group and Ri and R2 include H. The 6-disubstituted bicyclic nucleosides are useful for enhancing properties of oligomeric compounds including nuclease resistance. In certain embodiments, the oligomeric compounds provided herein hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.

  本公开描述了6-二取代双环核苷酸、从中制备的寡聚化合物以及使用这些寡聚化合物的方法。更具体地说，这些6-二取代双环核苷酸每个包括一个2′-O—C(Ri)(R2)-4′或2′-O—C=(R3)(R4)-4′桥，其中每个R独立地是一个取代基，而Ri和R2包括H。这些6-二取代双环核苷酸对增强包括核酸酶抗性在内的寡聚化合物的性质是有用的。在某些实施例中，本文提供的寡聚化合物与靶RNA的部分杂交，导致靶RNA的正常功能丧失。
• 6-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS
  申请人：Swayze Eric E.

  公开号：US20090012281A1

  公开（公告）日：2009-01-08

  The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 6-position. These bicyclicnucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance.
• N-Substituted-Aminomethylene Bridged Bicyclic Nucleic Acid Analogs
  申请人：Prakash Thazha P.

  公开号：US20100249211A1

  公开（公告）日：2010-09-30

  Provided herein are bicyeMc nucleosides comprising a substituted amino group in the bridge, oligomeric compounds having at least one of these bicyclic nucleosides and methods of using the oligomeric compounds. The bicyclic nucleosides comprising a substituted amino group in the bridge are useful for enhancing properties of oligomeric compounds including nuclease resistance, in certain embodiments, the oligomeric compounds hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
• US7399845B2
  申请人：——

  公开号：US7399845B2

  公开（公告）日：2008-07-15
• US7741457B2
  申请人：——

  公开号：US7741457B2

  公开（公告）日：2010-06-22