(1S)-2,3,4,6-Tetra-O-acetyl-1,5-anhydro-1-{3-[5-(4-fluorophenyl)thiophene-2-carbonyl]-4-methylphenyl}-D-glucitol | 1312811-00-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1S)-2,3,4,6-Tetra-O-acetyl-1,5-anhydro-1-{3-[5-(4-fluorophenyl)thiophene-2-carbonyl]-4-methylphenyl}-D-glucitol
• 英文别名: [(2R,3R,4R,5S,6S)-3,4,5-triacetyloxy-6-[3-[5-(4-fluorophenyl)thiophene-2-carbonyl]-4-methylphenyl]oxan-2-yl]methyl acetate
• CAS: 1312811-00-9
• 化学式: C₃₂H₃₁FO₁₀S
• 分子量: 626.6
• InChiKey: CCDRJKIEGRVBAT-CANUFQTHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  44
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  160
• 氢给体数：
  0
• 氢受体数：
  12

文献信息

• [EN] METHOD FOR PREPARATION OF 2,5-DISUBSTITUTED THIOPHENE COMPOUND<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN COMPOSÉ DE THIOPHÈNE 2,5-DISUBSTITUÉ
  申请人：TOPHARMAN SHANGHAI CO LTD

  公开号：WO2011079772A1

  公开（公告）日：2011-07-07

  A method for preparation of 2, 5-disubstituted thiophene compound I and its use for the preparation of compound V are disclosed. The said method comprises reacting compound II with compound III in the presence of a sulfur reagent to obtain compound I in a one-pot manner.