(4S,5S)-benzyl 5-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropyl)-2,2-dimethyl-4-(4-(pyridin-3-yl)benzyl)oxazolidine-3-carboxylate | 854755-87-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (4S,5S)-benzyl 5-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropyl)-2,2-dimethyl-4-(4-(pyridin-3-yl)benzyl)oxazolidine-3-carboxylate
• 英文别名: benzyl (4S,5S)-5-{(2S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropyl}-2,2-dimethyl-4-[4-(3-pyridinyl)benzyl]-1,3-oxazolidine-3-carboxylate；benzyl (4S,5S)-2,2-dimethyl-5-[(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropyl]-4-[(4-pyridin-3-ylphenyl)methyl]-1,3-oxazolidine-3-carboxylate
• CAS: 854755-87-6
• 化学式: C₃₉H₄₅N₃O₅
• 分子量: 635.803
• InChiKey: UFTMPVPNVGUTKZ-IMKBVMFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  47
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  90
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (4S,5S)-benzyl 5-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropyl)-2,2-dimethyl-4-(4-(pyridin-3-yl)benzyl)oxazolidine-3-carboxylate 在 palladium hydroxide on carbon 盐酸 、 氢气 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 2.5h， 生成 tert-butyl (1S,3S,4S)-4-amino-1-benzyl-3-hydroxy-5-[4-(3-pyridinyl)phenyl]pentylcarbamate hydrochloride
  参考文献：
  名称：

  HIV protease inhibiting compounds

  摘要：

  公开了一种公式的化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

  公开号：

  US20050131017A1
• 作为产物：
  描述：

  (4S)-5-[4-(benzyloxy)phenyl]-4-(dibenzylamino)-3-oxopentanenitrile 在 4-二甲氨基吡啶 、 bis-triphenylphosphine-palladium(II) chloride 、 sodium tetrahydroborate 、 甲烷磺酸 、 palladium 10% on activated carbon 、 甲酸铵 、 potassium carbonate 、 对甲苯磺酸 、 三乙胺 、 N,N-二异丙基乙胺 、 lithium chloride 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 、 甲基叔丁基醚 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 131.0h， 生成 (4S,5S)-benzyl 5-((S)-2-(tert-butoxycarbonylamino)-3-phenylpropyl)-2,2-dimethyl-4-(4-(pyridin-3-yl)benzyl)oxazolidine-3-carboxylate
  参考文献：
  名称：

  P1-Substituted Symmetry-Based Human Immunodeficiency Virus Protease Inhibitors with Potent Antiviral Activity against Drug-Resistant Viruses

  摘要：

  Because there is currently no cure for HIV infection, patients must remain on long-term drug therapy, leading to concerns over potential drug side effects and the emergence of drug resistance. For this reason, new and safe antiretroviral agents with improved potency against drug-resistant strains of HIV are needed. A series of HIV protease inhibitors (PIs) with potent activity against both wild-type (WT) virus and drug-resistant strains of HIV was designed and synthesized. The incorporation of substituents with hydrogen bond donor and acceptor groups at the PI position of our symmetry-based inhibitor series resulted in significant potency improvements against the resistant mutants. By this approach, several compounds, such as 13, 24, and 29, were identified that demonstrated similar or improved potencies compared to 1 against highly mutated strains of HIV derived from patients who previously failed HIV PI therapy. Overall, compound 13 demonstrated the best balance of potency against drug resistant strains of HIV and oral bioavailability in pharmacokinetic studies. X-ray analysis of an HIV PI with an improved resistance profile bound to WT HIV protease is also reported.

  DOI：

  10.1021/jm201109t

文献信息

• HIV Protease Inhibiting Compounds
  申请人：DeGoey David A.

  公开号：US20100249181A1

  公开（公告）日：2010-09-30

  A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

  公开了一种化合物，其化学式为，用作HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。
• US7834043B2
  申请人：——

  公开号：US7834043B2

  公开（公告）日：2010-11-16