N-(3-{3-[4-(2-Amino-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-5-tert-butyl-2-methoxy-phenyl)-methanesulfonamide | 473271-63-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(3-{3-[4-(2-Amino-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureido}-5-tert-butyl-2-methoxy-phenyl)-methanesulfonamide
• 英文别名: 1-[4-(2-Aminopyrimidin-4-yl)oxynaphthalen-1-yl]-3-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]urea
• CAS: 473271-63-5
• 化学式: C₂₇H₃₀N₆O₅S
• 分子量: 550.638
• InChiKey: ZLGCSDZGCRPTSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  166
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• 1,4-Disubstituted benzo-fused compounds
  申请人：——

  公开号：US20030083333A1

  公开（公告）日：2003-05-01

  Disclosed are novel 1,4-disubstituted benzo-fused compounds wherein G, X, L, Q, n and Y are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds. 1

  揭示了一种新型的1,4-二取代苯并化合物，其中G、X、L、Q、n和Y在此定义。这些化合物在制备用于治疗涉及炎症的疾病或病理状况的药物组合物中很有用，如慢性炎症性疾病。还公开了制备这些化合物的方法。
• Compounds useful as anti-inflammatory agents
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US20030008868A1

  公开（公告）日：2003-01-09

  Disclosed are compounds useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.

  公开了一些化合物，可用于制备用于治疗涉及炎症的疾病或病理状况，如慢性炎症性疾病的药物组合物。还公开了制备这些化合物的方法。
• KINASE INHIBITORS
  申请人：Respivert Limited

  公开号：US20150166483A1

  公开（公告）日：2015-06-18

  There is provided a compound of formula I, which compound has antiinflammatory activity (e.g. through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases, e.g., Src and Lck) and has use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.

  提供了一种化合物I的公式，该化合物具有抗炎活性（例如通过抑制以下一种或多种成员：p38有丝分裂原活化蛋白激酶酶家族；Syk激酶；以及酪氨酸激酶Src和Lck的成员），并可用于治疗，包括制药组合物中，特别是用于治疗炎症性疾病，包括肺部、眼睛和肠道的炎症性疾病。
• 1,4-DISUBSTITUTED BENZO-FUSED COMPOUNDS
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP1381592A1

  公开（公告）日：2004-01-21
• DIARYLUREA DERIVATIVES USEFUL AS ANTI-INFLAMMATORY AGENTS
  申请人：BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

  公开号：EP1392661A1

  公开（公告）日：2004-03-03