4-(5-Methanesulfonylmethyl-3-methyl-isoxazol-4-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester | 148383-75-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-(5-Methanesulfonylmethyl-3-methyl-isoxazol-4-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester
• CAS: 148383-75-9
• 化学式: C₁₉H₂₆N₂O₇S
• 分子量: 426.491
• InChiKey: LHIQJVXVUUHOCH-UHFFFAOYSA-N

物化性质

• 沸点：
  620.2±55.0 °C(predicted)
• 密度：
  1.255±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  溴甲苯 、 4-(5-Methanesulfonylmethyl-3-methyl-isoxazol-4-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 在 lithium diisopropyl amide 作用下， 生成 4-[5-(1-Methanesulfonyl-2-phenyl-ethyl)-3-methyl-isoxazol-4-yl]-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  Electrophilic quenching of dianions of 4-[5′-sulfonylmethylisoxazolyl]-1,4-dihydropyridines. A direct route to functionalized Hantzsch Esters

  摘要：

  An expedient entry into the preparation of Hantzsch Esters is presented. The method involves dilithiation and selective electrophilic quenching of 4-[5'-sulfonylmethylisoxazolyl]-1,4-dihydropyridines.

  DOI：

  10.1016/s0040-4039(00)77500-9
• 作为产物：
  描述：

  4-(4,4-Dimethyl-4,5-dihydro-oxazol-2-yl)-5-methanesulfonylmethyl-3-methyl-isoxazole 在 ammonium hydroxide 作用下， 生成 4-(5-Methanesulfonylmethyl-3-methyl-isoxazol-4-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester
  参考文献：
  名称：

  Electrophilic quenching of dianions of 4-[5′-sulfonylmethylisoxazolyl]-1,4-dihydropyridines. A direct route to functionalized Hantzsch Esters

  摘要：

  An expedient entry into the preparation of Hantzsch Esters is presented. The method involves dilithiation and selective electrophilic quenching of 4-[5'-sulfonylmethylisoxazolyl]-1,4-dihydropyridines.

  DOI：

  10.1016/s0040-4039(00)77500-9