N,N,N′,N′-tetramethylethylenediamine(1,1-cyclobutanedicarboxylato)platinum(II) | 306972-60-1

• 英文名称: N,N,N′,N′-tetramethylethylenediamine(1,1-cyclobutanedicarboxylato)platinum(II)
• 英文别名: cis-Pt(Me4en)(1,1-cyclobutanedicarboxylato)；[Pt(temed)(cbdca-2H)]
• CAS: 306972-60-1
• 化学式: C₁₂H₂₂N₂O₄Pt
• 分子量: 453.398
• InChiKey: ZHJOAHXPHCKWMZ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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文献信息

• DNA binding studies of a series of cis-[Pt(Am)2X2] complexes (Am=inert amine, X=labile carboxylato ligand)
  作者：Esther Escribano、Mercè Font-Bardia、Teresa Calvet、Julia Lorenzo、Patrick Gamez、Virtudes Moreno

  DOI：10.1016/j.ica.2012.07.018

  日期：2013.1

  A series of platinum(II) complexes of formulae cis-[Pt(Am)(2)X-2] (where Am represents an inert amine and X a labile (carboxylato) ligand) have been prepared and characterized by elemental analysis, ESI-MS, IR and H-1 NMR spectroscopy. The single-crystal molecular structures were determined for cis-[Pt(opea)(cbdca-2H)], cis-[Pt(hmpy)(cbdca-2H)], cis-[Pt(NH3)(2)(bzmal-2H)] and cis-[Pt(hmpy)(mu-dcch-2H)(2)] (where opea is picolylamine, hmpy represents 4-hydroxymethylpyridine, cbdca-2H, is 1,1-cyclobutanedicarboxylate anion, bzmal-2H stands for benzylmalonate anion and dcch-2H is trans-1,2-cyclohexanedicarboxylate anion). The interaction of all compounds with DNA was investigated with different techniques: viscosity measurements and emission fluorescence spectroscopy were used to investigate the changes induced by the binding of the platinum compounds to calf-thymus DNA, while atomic force microscopy and electrophoretic mobility allowed evaluating the potential alterations of pBR322 plasmid DNA. The cytotoxic behavior of the platinum compounds on human leukemia HL-60 tumor cell lines was also examined. (C) 2012 Elsevier B. V. All rights reserved.
• Synthesis and characterization of Pt(II) complexes with amine and carboxylato ligands. Crystal structure of (1,1-cyclobutanedicarboxylato)di(ethylamine)platinum(II)·H2O
  作者：Fernande D Rochon、Letitia M Gruia

  DOI：10.1016/s0020-1693(00)00171-7

  日期：2000.8

  Two methods for the synthesis of compounds of the type cis-PtA(2)X(2) (A(2) = bidentate amine or two monodentate amines and X-2 = bidentate or two monodentate carboxylato ligands) were evaluated. The compounds were characterized by multinuclear NMR and IR spectroscopies. The Pt-195 NMR chemical shifts were in the range -1615 to -1976 ppm, the higher field values corresponding to the complexes containing bidentate ligands. The coupling constants (3)J(Pt-195-H-1) are approximately 35 Hz, while the (2)J(Pt-195-(HN)-H-1) are about 70 Hz. One coupling constant (2)J(Pt-195-C-13) (53 Hz) was also measured. The crystal structure of the compound, cis-Pt(1,1-cyclobutanedicarboxylato)(C2H5NH2)(2). H2O belongs to the P2(1)/n space group with a = 9.468(5), b = 9.365(4), c = 16.473(7) Angstrom, beta = 105.08(3)degrees, Z = 4 and R-1 = 0.0576. The Pt-N bond distances are 1.992(5) and 2.020(5) Angstrom, while the Pt-O bonds are 2.000(4) and 2.015(4) Angstrom. The molecules are held together by intermolecular H-bonds involving the lattice water molecules and the two free carbonyl O atoms and between the amino H atoms and the Pt-bonded C-O groups. (C) 2000 Elsevier Science S.A. All rights reserved.