(2S,4R)-tert-butyl 4-(benzyloxy)-2-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)pyrrolidine-1-carboxylate | 918313-61-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (2S,4R)-tert-butyl 4-(benzyloxy)-2-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)pyrrolidine-1-carboxylate
• CAS: 918313-61-8
• 化学式: C₂₅H₃₀N₄O₃
• 分子量: 434.538
• InChiKey: QXFYYXSWTWYAQE-FCHUYYIVSA-N

物化性质

• 沸点：
  587.0±60.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  (2S,4R)-tert-butyl 4-(benzyloxy)-2-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)pyrrolidine-1-carboxylate 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 以32%的产率得到(2S,4R)-4-Hydroxy-2-(4-phenyl-[1,2,3]triazol-1-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Evolution of Pyrrolidine-Type Asymmetric Organocatalysts by “Click” Chemistry

  摘要：

  [GRAPHICS]Click chemistry has been employed to construct a library of the pyrrolidine-type asymmetric organocatalysts. The clicked organocatalysts were evaluated in asymmetric Michael addition of ketones to nitroolefins, showing good catalytic activity and stereoselectivity (up to 100% yield, syn:anti=99:1, 96% ee).

  DOI：

  10.1021/jo061657r
• 作为产物：
  描述：

  (2S,4R)-2-Azidomethyl-4-benzyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester 、 苯乙炔 在 copper(l) iodide 、 N,N-二异丙基乙胺 作用下， 以 甲苯 、 叔丁醇 为溶剂， 生成 (2S,4R)-tert-butyl 4-(benzyloxy)-2-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)pyrrolidine-1-carboxylate
  参考文献：
  名称：

  Evolution of Pyrrolidine-Type Asymmetric Organocatalysts by “Click” Chemistry

  摘要：

  [GRAPHICS]Click chemistry has been employed to construct a library of the pyrrolidine-type asymmetric organocatalysts. The clicked organocatalysts were evaluated in asymmetric Michael addition of ketones to nitroolefins, showing good catalytic activity and stereoselectivity (up to 100% yield, syn:anti=99:1, 96% ee).

  DOI：

  10.1021/jo061657r