8-(2,4-dichlorophenyl)-6-(butylthio)-1,2,3,4,4a,9b,-hexahydro[1]benzofuro[3,2-c]-pyridine | 488125-14-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮
• 英文名称: 8-(2,4-dichlorophenyl)-6-(butylthio)-1,2,3,4,4a,9b,-hexahydro[1]benzofuro[3,2-c]-pyridine
• 英文别名: 6-Butylsulfanyl-8-(2,4-dichlorophenyl)-1,2,3,4,4a,9b-hexahydro-[1]benzofuro[3,2-c]pyridine
• CAS: 488125-14-0
• 化学式: C₂₁H₂₃Cl₂NOS
• 分子量: 408.392
• InChiKey: AIKAJQVNDBPDSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  46.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Therapeutic compounds
  申请人：——

  公开号：US20030050304A1

  公开（公告）日：2003-03-13

  The present invention provides compounds of formula (I): 1 wherein: R 1 , R 2 , R 3 R 4 , R 5 , R 6 , X, - - - , m, and n have any of the values defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts thereof. The invention also provides therapeutic methods as well as processes and intermediates useful for preparing compounds of formula (I). The compounds are useful as 5-HT ligands.

  本发明提供式（I）的化合物：其中：R1，R2，R3，R4，R5，R6，X，-，-，-，m和n具有规范中定义的任何值，以及包括该化合物或其盐的制药组合物。本发明还提供治疗方法以及用于制备式（I）化合物的过程和中间体。这些化合物可用作5-HT配体。
• (HETERO)ARYL SUBSTITUTED BENZOFURANS AS 5-HT LIGANDS
  申请人：PHARMACIA & UPJOHN COMPANY

  公开号：EP1404679A2

  公开（公告）日：2004-04-07
• US6762191B2
  申请人：——

  公开号：US6762191B2

  公开（公告）日：2004-07-13
• [EN] THERAPEUTIC COMPOUNDS<br/>[FR] COMPOSES THERAPEUTIQUES
  申请人：UPJOHN CO

  公开号：WO2003004501A2

  公开（公告）日：2003-01-16

  The present invention provides coupounds of formula (I): wherein R1, R2, R3, R4, R5, R6, X, ---, m, and n have any of the values defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts thereof. The invention also provides therapeutic methods as well as processes and intermediates useful for preparing compounds of formula (I). The compounds are useful as 5-HT ligands.