3-(2-dimethylaminomethyl-1-hydroxy-cyclohexyl)phenyl 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate | 269079-75-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-dimethylaminomethyl-1-hydroxy-cyclohexyl)phenyl 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate
• 英文别名: [3-[2-[(dimethylamino)methyl]-1-hydroxycyclohexyl]phenyl] 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate
• CAS: 269079-75-6
• 化学式: C₃₀H₃₄N₂O₄
• 分子量: 486.611
• InChiKey: RRSATROXEHXOFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Novel esters derived from (rr,ss)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl
  申请人：——

  公开号：US20030100598A1

  公开（公告）日：2003-05-29

  New esters derived from substituted phenyl-cyclohexyl compounds, which are derived from Tramadol, process for obtaining them and their use for preparing a drug with analgesic properties. These new compounds of general formula (I) have a higher analgesic activity, a lower toxicity and a longer effective time period than Tramadol.

  新的酯类化合物来源于取自曲马多（Tramadol）的取代苯基-环己基化合物，其制备方法以及它们用于制备具有镇痛性质的药物。这些新化合物的通式（I）具有比曲马多更高的镇痛活性，更低的毒性和更长的有效时间。
• NEW ESTERS DERIVED FROM SUBSTITUTED PHENYL-CYCLOHEXYL COMPOUNDS
  申请人：VITA-INVEST, S.A.

  公开号：EP1127871A1

  公开（公告）日：2001-08-29

  New csters derived from substituted phenyl cyclohexyl compounds, which are derived from Tramadol, process for obtaining them and their use for preparing a drug with analgesic properties. These new compounds of general formula (I) have a higher analges activcity, a lower toxicity and a longer effective time period than Tramadol.

  从曲马多衍生的取代苯基环己基化合物的新酯类、获得过程及其在制备具有镇痛特性的药物中的用途。与曲马多相比，这些通式（I）的新化合物具有更高的镇痛活性、更低的毒性和更长的有效期。
• New esters derived from substituted phenyl-cyclohexyl compounds
  申请人：VITA-INVEST, S.A.

  公开号：EP1219623A1

  公开（公告）日：2002-07-03

  New esters derived from substituted phenylcyclohexyl compounds, which are derived from Tramadol, process for obtaining them and their use for preparing a drug with analgesic properties. These new compounds of general formula (I) have a higher analgesic activity, a lower toxicity and a longer effective time period than Tramadol.

  由取代苯基环己基化合物衍生的新酯类，这些化合物是从曲马多衍生出来的，它们的获得过程以及它们在制备具有镇痛特性的药物中的用途。与曲马多相比，这些通式（I）的新化合物具有更高的镇痛活性、更低的毒性和更长的有效期。
• FUMAGILLOL DERIVATIVES AND PREPARING METHOD THEREOF
  申请人：Idrtech Inc.

  公开号：EP1436286A1

  公开（公告）日：2004-07-14
• EP1436286A4
  申请人：——

  公开号：EP1436286A4

  公开（公告）日：2004-12-15