哌嗪,2,4,6-三甲基-1-亚硝基-,顺-(9CI) | 82953-40-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 哌嗪,2,4,6-三甲基-1-亚硝基-,顺-(9CI)
• 英文名称: D-Mannuronic acid, 2,3-bis(acetylamino)-2,3-dideoxy-
• 英文别名: (2S,3S,4R,5S)-4,5-diacetamido-2,3-dihydroxy-6-oxohexanoic acid
• CAS: 82953-40-0
• 化学式: C₁₀H₁₆N₂O₇
• 分子量: 276.24
• InChiKey: NECLRKWCWAVXSY-HXFLIBJXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  153
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Bordetella vaccines comprising LPS with reduced reactogenicity
  申请人：De Staat der Nederlanden, vert. door de minister van VWS, Ministerie van Volksgezondheid, Welzijn en Sport

  公开号：US11291713B2

  公开（公告）日：2022-04-05

  The current invention lies in the field of medicine and more specifically in the field of vaccinology. The current invention concerns a novel Bordetella LPS and a modified bacterium of the genus Bordetella comprising such modified LPS. The LPS of the invention has a reduced endotoxicity in comparison to an unmodified Bordetella LPS. The modified LPS of the invention is therefore particularly suitable for use in inducing or stimulating an immune response in a subject, wherein the immune response is induced or stimulated against a Bordetella infection. The modified Bordetella LPS of the invention is obtainable by introducing in a Bordetella cell the expression of a heterologous acyl transferase. In particular, the modified Bordetella cell of the invention has an increased expression of an heterologous LpxA, LpxL or LpxD acyl transferase.

  本发明属于医学领域，更具体地说属于疫苗学领域。本发明涉及一种新型博德特氏菌 LPS 和包含这种改良 LPS 的改良博德特氏菌属细菌。本发明的 LPS 与未改良的博德特氏菌 LPS 相比，具有更低的内毒素。因此，本发明的改良 LPS 特别适用于诱导或刺激受试者的免疫反应，其中免疫反应是针对博德特氏菌感染诱导或刺激的。本发明的改良博德特氏菌 LPS 可通过在博德特氏菌细胞中引入异源酰基转移酶的表达来获得。特别是，本发明的改良波氏杆菌细胞具有异源 LpxA、LpxL 或 LpxD酰基转移酶表达量的增加。
• VERWENDUNG VON SEKUNDÄREM ZELLWANDPOLYMER PROKARYONTISCHER MIKROORGANISMEN
  申请人：NANO-S Biotechnologie GmbH

  公开号：EP1285003B1

  公开（公告）日：2004-09-08
• IMPROVED VACCINES AGAINST BORDETELLA PERTUSSIS BASED ON LPS GLYCOSYLTRANSFERASE MUTANTS
  申请人：De Staat der Nederlanden, vert. door de minister van VWS

  公开号：EP2134743A2

  公开（公告）日：2009-12-23
• BORDETELLA PERTUSSIS LOS-DERIVED OLIGOSACCHARIDE WITH PERTUSSIS TOXIN GLYCOCONJUGATE AND ITS APPLICATION IN THE PROPHYLAXIS AND TREATMENT OF INFECTIONS CAUSED BY BORDETELLA PERTUSSIS
  申请人：Wroclawskie Centrum Badan EIT + Sp. z o.o.

  公开号：EP3003389A1

  公开（公告）日：2016-04-13
• VACCINES AGAINST BORDETELLA PERTUSSIS BASED ON LPS GLYCOSYLTRANSFERASE MUTANTS
  申请人：Geurtsen Jeroen Johannes Gerardus

  公开号：US20100291153A1

  公开（公告）日：2010-11-18

  The invention relates to an improved vaccine against pertussis wherein mutants of Bordetella pertussis having a modified LPS molecule or the obtainable LPS molecules are used. These mutants or the obtainable LPS molecules may further be used as an adjuvant.