4-Chloro-6-(4-ethoxyphenoxy)pyrimidine | 607723-55-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Chloro-6-(4-ethoxyphenoxy)pyrimidine
• CAS: 607723-55-7
• 化学式: C₁₂H₁₁ClN₂O₂
• mdl: MFCD13197800
• 分子量: 250.68
• InChiKey: NJHLADBVZKDSSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Thiazolidinedione and pharmaceutical composition comprising the same
  申请人：——

  公开号：US20040122031A1

  公开（公告）日：2004-06-24

  The present invention relates to a thiazolidinedione derivative, represented in formula (1) below, pharmaceutically acceptable salts thereof, and/or pharmaceutically acceptable solvates thereof. Further, the present invention provides a pharmaceutical composition comprising the compound represented in formula (1) below, 1 wherein: X represents a carbon or nitrogen atom, Y represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen, or an aryl group, Z represents an oxygen, nitrogen, or sulfur atom, and R 1 and R 2 each represent a hydrogen atom; or R 1 and R 2 together form a bond.

  本发明涉及一种噻唑烷二酮衍生物，其表示为下式（1），其药学上可接受的盐和/或药学上可接受的溶剂。此外，本发明提供了一种含有下式（1）所表示的化合物的制药组合物，其中：X表示碳或氮原子，Y表示氢原子，烷基，烷氧基，卤素或芳基，Z表示氧，氮或硫原子，R1和R2各自表示氢原子；或R1和R2结合形成键。
• THIAZOLIDINEDIONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
  申请人：Chong Kun Dang Pharmaceutical Corp.

  公开号：EP1490360A1

  公开（公告）日：2004-12-29
• EP1490360A4
  申请人：——

  公开号：EP1490360A4

  公开（公告）日：2006-07-05
• US6787551B2
  申请人：——

  公开号：US6787551B2

  公开（公告）日：2004-09-07
• [EN] THIAZOLIDINEDIONE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME<br/>[FR] DERIVES DE THIAZOLIDINEDIONE ET COMPOSITION PHARMACEUTIQUE LES CONTENANT
  申请人：CHONG KUN DANG PHARM CORP

  公开号：WO2003080605A1

  公开（公告）日：2003-10-02

  The present invention relates to a thiazolidinedione derivative, represented in formula (1) below, pharmaceutically acceptable salts thereof, and/or pharmaceutically acceptable solvates thereof. Further, the present invention provides a pharmaceutical composition comprising the compound represented in formula (1) wherein: X represents a carbon or nitrogen atom, Y represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen, or an aryl group, Z represents an oxygen, nitrogen, or sulfur atom, and R1 and R2 each represent a hydrogen atom; or R1 and R2 together form a bond.