(3S,4R)-4-butyl-3-hydroxy-5-(1-iodoethyl)-3-methyldihydrofuran-2(3H)-one | 1187335-45-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: (3S,4R)-4-butyl-3-hydroxy-5-(1-iodoethyl)-3-methyldihydrofuran-2(3H)-one
• CAS: 1187335-45-0
• 化学式: C₁₁H₁₉IO₃
• 分子量: 326.175
• InChiKey: KQDUTWUQHRYREN-LURLDICESA-N

反应信息

• 作为产物：
  描述：

  (2S,3R)-2-hydroxy-2-methyl-3-((E)-prop-1-enyl)heptanoicacid 在 碘 、 碳酸氢钠 作用下， 以 乙腈 为溶剂， 反应 10.0h， 以48%的产率得到(3S,4R)-4-butyl-3-hydroxy-5-(1-iodoethyl)-3-methyldihydrofuran-2(3H)-one
  参考文献：
  名称：

  Silylene transfer to α-keto esters and application to the synthesis of γ-lactones

  摘要：

  Disubstituted alpha-hydroxy acids have been synthesized by metal-catalyzed silylene transfer to alpha-keto esters. A range of substituents are tolerated in the transformation with the exception of branched groups at the vinylic position. The alpha-hydroxy acid products can be converted into gamma-lactones using a variety of lactonization conditions. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.05.066