[3-(丙-2-基)氧杂环丁-3-基]甲醇 | 97720-51-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环丁烷
• 中文名称: [3-(丙-2-基)氧杂环丁-3-基]甲醇
• 英文名称: [3-(Propan-2-yl)oxetan-3-yl]methanol
• 英文别名: (3-propan-2-yloxetan-3-yl)methanol
• CAS: 97720-51-9
• 化学式: C₇H₁₄O₂
• 分子量: 130.18
• InChiKey: FMUFFUZPAMYTLG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-硝基苯甲酰氯 、 [3-(丙-2-基)氧杂环丁-3-基]甲醇 生成 (3-propan-2-yloxetan-3-yl)methyl 4-nitrobenzoate
  参考文献：
  名称：

  PALMER, C. J.;CASIDA, J. E., J. AGR. AND FOOD CHEM., 1985, 33, N 5, 976-980

  摘要：

  DOI：

文献信息

• Purinone Derivatives as Tyrosine Kinase Inhibitors
  申请人：Principia Biopharma Inc.

  公开号：US20140142099A1

  公开（公告）日：2014-05-22

  The present disclosure provides compounds and pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as autoimmune diseases, cancer and inflammatory diseases. Also provided are pharmaceutical compositions containing such compounds and pharmaceutically acceptable salts thereof and processes for preparing such compounds and pharmaceutically acceptable salts thereof.

  本公开提供了一些酪氨酸激酶抑制剂及其药用盐，特别是BLK、BMX、EGFR、HER2、HER4、ITK、TEC、BTK和TXK，因此适用于治疗通过抑制酪氨酸激酶可治疗的疾病，如自身免疫疾病、癌症和炎症性疾病。还提供了含有这些化合物和药用盐的药物组合物，以及制备这些化合物和药用盐的方法。
• Cyclohexene Oxide Compound Having Cyclohexyl Group or Long-Chain Alkyl Group, and Use Thereof
  申请人：Kato Hisao

  公开号：US20080108725A1

  公开（公告）日：2008-05-08

  An object of the present invention is to provide a cyclohexene oxide compound that gives a cured resin having a low refractive index and excellent transparency, curability, mold release properties, and mechanical properties, and that can be used as a component of an actinic radiation curing composition and/or heat curing composition. The present invention is a cyclohexene oxide compound having a cyclohexyl group or a long-chain alkyl group, represented by Formula (1) below (in Formula (1), A denotes a cyclohexyl group, Formula (2) below, or an optionally branched alkyl group having 8 to 16 carbons) (in Formula (2), R 1 denotes a hydrogen atom or an optionally branched alkyl group having 1 to 4 carbons and R 2 denotes a hydrogen atom or an optionally branched alkyl group having 1 to 4 carbons).

  本发明的目的是提供一种环己烯氧化物化合物，该化合物能够产生具有低折射率和优异透明度、可固化性、模具脱模性和机械性能的固化树脂，并可用作光敏辐射固化组合物和/或热固化组合物的组分。本发明是一种具有环己基或长链烷基的环己烯氧化物化合物，由下式（1）表示（在式（1）中，A表示环己基、下式（2）或具有8至16个碳的可选支链烷基）（在式（2）中，R1表示氢原子或具有1至4个碳的可选支链烷基，R2表示氢原子或具有1至4个碳的可选支链烷基）。
• GLYOXAMIDE SUBSTITUTED PYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B
  申请人：Janssen Sciences Ireland UC

  公开号：US20160176817A1

  公开（公告）日：2016-06-23

  Inhibitors of HBV replication of Formula (IA) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein X and R 1 to R 6 have the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.

  本发明涉及一种HBV复制的抑制剂Formula（IA），包括立体化学异构体形式和其盐、水合物、溶剂物，其中X和R1至R6的含义如本文所定义。本发明还涉及制备上述化合物的过程，含有它们的制药组合物及其在HBV治疗中的使用，单独或与其他HBV抑制剂结合使用。
• PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF
  申请人：YU Henry

  公开号：US20160152626A1

  公开（公告）日：2016-06-02

  The present invention relates to pyrazole compounds, and pharmaceutically acceptable compositions thereof, useful as positive allosteric modulators of follicle stimulating hormone receptor (FSHR).

  本发明涉及吡唑化合物及其药学上可接受的组合物，作为卵泡刺激素受体（FSHR）的正向变构调节剂。
• A class of pesticides comprising 1,4-bis-substituted-2,6,7-trioxabicyclo(2.2.2)octanes
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：EP0152229A2

  公开（公告）日：1985-08-21

  A pesticidal composition comprising a compound having the formula R-C(CH2O)3C-X wherein R and X are each organic substituents and wherein the compound has an LD50, in micrograms of compound per gram of body weight of Musca domestica, of less than about 400 and or an LD50 in the presence of synergist of less than about 60 is disclosed along with its use in killing pests. Pesticidal activity has been found against a broad range of types of insects. The pesticidal activity of the composition is strongly enhanced by the use of a selected synergist.

  本发明公开了一种杀虫组合物，该组合物包含一种具有式 R-C(CH2O)3C-X 的化合物，其中 R 和 X 分别为有机取代基，并且该化合物在每克家蝇（Musca domestica）体重中的半数致死剂量（以微克计）小于约 400，或在增效剂存在下的半数致死剂量小于约 60。已发现其对多种类型的昆虫具有杀虫活性。该组合物的杀虫活性通过使用一种选定的增效剂而大大增强。