4,5-二氯-1,2-二甲基-1H-咪唑 | 175201-56-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4,5-二氯-1,2-二甲基-1H-咪唑
• 英文名称: 1,2-Dimethyl-4,5-dichlorimidazol
• 英文别名: 4,5-dichloro-1,2-dimethyl-1H-imidazole；4,5-Dichloro-1,2-dimethylimidazole
• CAS: 175201-56-6
• 化学式: C₅H₆Cl₂N₂
• mdl: MFCD00067909
• 分子量: 165.022
• InChiKey: OWNKAADCKPAOHY-UHFFFAOYSA-N

物化性质

• 熔点：
  52-56°C
• 沸点：
  282.5±20.0 °C(Predicted)
• 密度：
  1.41±0.1 g/cm3(Predicted)
• 稳定性/保质期：
  **避氧化物**

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Isoxazoline-substituted benzamide compound and pesticide
  申请人：Mita Takeshi

  公开号：US20070066617A1

  公开（公告）日：2007-03-22

  An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: wherein A 1 , A 2 and A 3 independently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., X is halogen atom, C 1 -C 6 haloalkyl, etc., Y is halogen atm, C 1 -C 6 alkyl, etc., R 1 is C 1 -C 12 alkyl arbitrarily substituted with R 16 , C 3 -C 2 alkenyl, arbitrarily substituted with R 16 is oxygen atom or sulfur atom, —N(R 20 )R 19 , etc., R 2 is hydrogen atom, C 1 -C 4 alkoxy C 1 -C 6 alkyl, etc., R 3 is C 1 -C 6 haloalkyl, etc., R 16 is halogen atom, cyano, phenyl substituted with (Z) p1 , D-1 to D-60, E-1 to E-49, etc., R 19 is phenyl, phenyl substituted with (Z) p1 , etc., R 20 is hydrogen atom, C 1 -C 6 alkyl, etc., Z is halogen atom, nitro, C 1 -C 4 alkoxy, etc., D-1 to D-60 are 5- or 6-membered aromatic heterocyclic rings, E-1 to E-49 are 5- or 6-membered saturated heterocyclic rings, m is an integer of 0 to 5, n is an integer of 0 to 4, p1 is an integer of 1 to 5. The pesticide containing these compounds.

  一种公式（1）所示的异噁唑基取代的苯甲酰胺化合物或其盐： 其中A1，A2和A3独立地为碳原子或氮原子，G为苯环等，X为卤素原子，C1-C6卤代烷基等，Y为卤素原子，C1-C6烷基等，R1是任意取代的C1-C12烷基，或者任意取代的C3-C2烯基，取代基为R16，R16是卤素原子，氰基，苯基取代的（Z）p1，D-1至D-60，E-1至E-49等，R2为氢原子，C1-C4烷氧基C1-C6烷基等，R3为C1-C6卤代烷基等，R19为苯基，苯基取代的（Z）p1等，R20为氢原子，C1-C6烷基等，Z为卤素原子，硝基，C1-C4烷氧基等，D-1至D-60为5-或6-成员芳香杂环环，E-1至E-49为5-或6-成员饱和杂环，m为0至5的整数，n为0至4的整数，p1为1至5的整数。包含这些化合物的杀虫剂。
• Substituted benzanilide compound and noxious organism controlling agent
  申请人：Ikeda Eitatsu

  公开号：US20070043011A1

  公开（公告）日：2007-02-22

  The present invention is to provide a novel agrigultural chemical, particularly an insecticide or acaricide, and discloses a substituted benzanilide compound represented by the formula (1): wherein W 1 and W 2 each independently represent an oxygen atom or a sulfur atom, X represents a halogen atom, etc., Y represents C 1 to C 6 alkyl, etc., R 1 represents C 1 to C 12 alkyl, a C 1 to C 6 alkylthio(C 1 to C 6 ) alkyl, a C 1 to C 6 alkylsulfinyl(C 1 to C 6 ) alkyl or a C 1 to C 6 alkylsulfonyl(C 1 to C 6 ) alkyl, etc., R 2 and R 3 each independently represent a hydrogen atom, etc., R 4 represents a C 1 to C 6 alkyl or a C 1 to C 6 haloalkyl, etc., R 5 represents a phenoxy(C 1 to C 6 ) haloalkyl substituted by (Z) p1 , a phenyl(C 2 to C 6 ) alkenyl, substituted by (Z) p1 phenyl, a phenyl substituted by (Z) p1 or L, etc., R 6 represents a hydrogen atom, a C 1 to C 12 alkyl, a C 1 to C 6 alkoxy(C 1 to C 6 ) alkyl or a C 1 to C 6 alkylcarbonyl, etc., L represents an aromatic heterocyclic ring such as L-1 to L-4, L-8 to L-13, L-15 to L-23, L-45 to L-52 or L-53, etc., Z represents a halogen atom, a C 1 to C 6 haloalkyl, a C 1 to C 6 haloalkoxy or a C 1 to C 6 haloalkoxy-(C 1 to C 6 ) haloalkoxy, etc., m and n each independently is an integer of 0 to 4, p1 is an integer or 1 to 5, or a salt thereof, and a noxious organism controlling agent containing these.

  本发明提供了一种新型农业化学品，特别是一种杀虫剂或螨虫剂，并披露了一种代表式（1）所示的取代苯甲酰胺化合物，其中W1和W2分别独立地表示氧原子或硫原子，X表示卤素原子等，Y表示C1到C6烷基等，R1表示C1到C12烷基，C1到C6烷基硫（C1到C6）烷基，C1到C6烷基亚砜（C1到C6）烷基或C1到C6烷基磺酰（C1到C6）烷基等，R2和R3各自独立地表示氢原子等，R4表示C1到C6烷基或C1到C6卤代烷基等，R5表示被（Z）p1取代的苯氧基（C1到C6）卤代烷基，被（Z）p1苯基取代的苯基（C2到C6）烯基，被（Z）p1或L取代的苯基等，R6表示氢原子，C1到C12烷基，C1到C6烷氧基（C1到C6）烷基或C1到C6烷基羰基等，L表示芳香族杂环环，例如L-1到L-4，L-8到L-13，L-15到L-23，L-45到L-52或L-53等，Z表示卤素原子，C1到C6卤代烷基，C1到C6卤代烷氧基或C1到C6卤代烷氧基-（C1到C6）卤代烷氧基等，m和n各自独立地是0到4的整数，p1是1到5的整数，或其盐，以及含有这些的有害生物控制剂。
• CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
  申请人：Carter Percy H.

  公开号：US20100063067A1

  公开（公告）日：2010-03-11

  The present application describes modulators of MIP-1α of formula (I), or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein n, A, T, R 1 , R 2 and R 8 , are as defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using the modulators of formula (I) are disclosed.

  本申请描述了MIP-1α的调节剂，其化学式为(I)，或其立体异构体或前药或药学上可接受的盐，其中n、A、T、R1、R2和R8如本文所定义。此外，还公开了使用化合物(I)的调节剂治疗和预防炎症性疾病，如哮喘和过敏性疾病，以及自身免疫病理学疾病，如类风湿性关节炎和动脉硬化的方法。
• ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE
  申请人：Mita Takeshi

  公开号：US20090312330A1

  公开（公告）日：2009-12-17

  An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: wherein A 1 , A 2 and A 3 independently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., X is halogen atom, C 1 -C 6 haloalkyl, etc., Y is halogen atm, C 1 -C 6 alkyl, etc., R 1 is C 1 -C 12 alkyl arbitrarily substituted with R 16 , C 3 -C 12 alkenyl, arbitrarily substituted with R 16 is oxygen atom or sulfur atom, —N(R 20 )R 19 , etc., R 2 is hydrogen atom, C 1 -C 4 alkoxy C 1 -C 6 alkyl, etc., R 3 is C 1 -C 6 haloalkyl, etc., R 16 is halogen atom, cyano, phenyl substituted with (Z) p1 , D-1 to D-60, E-1 to E-49, etc., R 19 is phenyl, phenyl substituted with (Z) p1 , etc., R 20 is hydrogen atom, C 1 -C 6 alkyl, etc., Z is halogen atom, nitro, C 1 -C 4 alkoxy, etc., D-1 to D-60 are 5- or 6-membered aromatic heterocyclic rings, E-1 to E-49 are 5- or 6-membered saturated heterocyclic rings, m is an integer of 0 to 5, n is an integer of 0 to 4, p1 is an integer of 1 to 5. The pesticide containing these compounds.

  一种公式（1）的异氧杂环取代苯甲酰胺化合物或其盐： 其中，A1，A2和A3独立地是碳原子或氮原子，G是苯环等，X是卤素原子，C1-C6卤代烷基等，Y是卤素原子，C1-C6烷基等，R1是任意取代R16的C1-C12烷基，任意取代R16的C3-C12烯基，是氧原子或硫原子，-N（R20）R19等，R2是氢原子，C1-C4烷氧基C1-C6烷基等，R3是C1-C6卤代烷基等，R16是卤素原子，氰基，苯基，其上取代有（Z）p1，D-1至D-60，E-1至E-49等，R19是苯基，其上取代有（Z）p1等，R20是氢原子，C1-C6烷基等，Z是卤素原子，硝基，C1-C4烷氧基等，D-1至D-60是5-或6-成员芳香杂环，E-1至E-49是5-或6-成员饱和杂环，m是0至5的整数，n是0至4的整数，p1是1至5的整数。含有这些化合物的杀虫剂。
• Alpha-cinnamide compounds and compositions as HDAC8 inhibitors
  申请人：FORMA Therapeutics, Inc.

  公开号：US10266487B2

  公开（公告）日：2019-04-23

  The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.

  本发明涉及组蛋白去乙酰化酶（尤其是 HDAC8）的抑制剂，可用于治疗癌症及其他疾病和失调，还涉及上述抑制剂的合成和应用。