1-Methyl-2t-methylamino-cyclohexan-1r-ol | 90226-54-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Methyl-2t-methylamino-cyclohexan-1r-ol
• 英文别名: Rac-(1r,2r)-1-methyl-2-(methylamino)cyclohexan-1-ol；(1R,2R)-1-methyl-2-(methylamino)cyclohexan-1-ol
• CAS: 90226-54-3
• 化学式: C₈H₁₇NO
• 分子量: 143.229
• InChiKey: KMMPFGUVUKURFE-HTQZYQBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] TECHNOLOGIES USEFUL FOR OLIGONUCLEOTIDE PREPARATION<br/>[FR] TECHNOLOGIES UTILES POUR LA PRÉPARATION D'OLIGONUCLÉOTIDES
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2020191252A1

  公开（公告）日：2020-09-24

  Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.

  除其他事项外，本公开提供了寡核苷酸制备技术，特别是手性控制的寡核苷酸制备技术，这些技术大大提高了粗品纯度和产量，并显著降低了制造成本。
• [EN] COMPOSITIONS AND METHODS FOR PHOSPHORAMIDITE AND OLIGONUCLEOTIDE SYNTHESIS<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE SYNTHÈSE DE PHOSPHORAMIDITES ET D'OLIGONUCLÉOTIDES
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2018098264A1

  公开（公告）日：2018-05-31

  The present disclosure, among other things, provides technologies for oligonucleotide synthesis. In some embodiments, the present disclosure provides phosphoramidites and methods for synthesis thereof. In some embodiments, provided methods provides higher yields and/or purities. In some embodiments, provided methods remove byproducts without contact with an aqueous solution.

  本公开内容提供了寡核苷酸合成的技术。在某些实施例中，本公开内容提供了磷酰胺酰胺和其合成方法。在某些实施例中，所提供的方法提供了更高的产率和/或纯度。在某些实施例中，所提供的方法在不与水溶液接触的情况下去除副产物。
• TECHNOLOGIES FOR OLIGONUCLEOTIDE PREPARATION
  申请人：BOWMAN Keith Andrew

  公开号：US20200231620A1

  公开（公告）日：2020-07-23

  Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.
• [EN] TECHNOLOGIES FOR OLIGONUCLEOTIDE PREPARATION<br/>[FR] TECHNOLOGIES DE PRÉPARATION D'OLIGONUCLÉOTIDES
  申请人：WAVE LIFE SCIENCES LTD

  公开号：WO2019055951A1

  公开（公告）日：2019-03-21

  Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.