1-(2-hydroxy-4-methoxymethyloxyphenyl)-3-phenylpropynone | 1165713-49-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-(2-hydroxy-4-methoxymethyloxyphenyl)-3-phenylpropynone
• CAS: 1165713-49-4
• 化学式: C₁₇H₁₄O₄
• 分子量: 282.296
• InChiKey: UPRUNXDCEUSBGB-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  1-(2-(4-methoxy)benzyloxy-4-(methoxymethyloxy)phenyl)-3-phenylprop-2-yn-1-one 在 甲醇 、 amberlyst-15 作用下， 以 甲苯 为溶剂， 反应 0.25h， 以67%的产率得到1-(2-hydroxy-4-methoxymethyloxyphenyl)-3-phenylpropynone
  参考文献：
  名称：

  Factors affecting orthogonality in the deprotection of 2,4-di-protected aromatic ethers employing solid-supported acids

  摘要：

  Selective deprotection of aromatic ethers bearing two protecting groups on the same aromatic ring by solid-supported acids (Amberlyst-15 and PTS-Si) was systematically investigated. ortho-Directing protonation by the carbonyl group as well as carbocation stability and quenching are the important determining factors for the orthogonal deprotection process. Stablilized carbocations (e.g., those from the MOM and PMB groups) could be removed with high selectivity. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.03.089