4-(2-fluorophenyl)-1,2-diphenyl-1H-imidazole | 1610784-73-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(2-fluorophenyl)-1,2-diphenyl-1H-imidazole
• CAS: 1610784-73-0
• 化学式: C₂₁H₁₅FN₂
• 分子量: 314.362
• InChiKey: SHTZDFDRSNBFGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.35
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.82
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  2'-氟苯乙酮 、 N-苯基苄脒 在 1,10-菲罗啉 、 copper diacetate 、 苯胺 、 lithium bromide 、 zinc(II) iodide 作用下， 以 邻二氯苯 为溶剂， 反应 2.0h， 以68%的产率得到4-(2-fluorophenyl)-1,2-diphenyl-1H-imidazole
  参考文献：
  名称：

  Copper and zinc co-catalyzed synthesis of imidazoles via the activation of sp3 C–H and N–H bonds

  摘要：

  An efficient and facile approach to synthesize imidazoles from amidines and arylketone via oxidative coupling of sp(3) C-H bond and N-H bond is reported. This strategy exhibits high performance in terms of regioselectivity with moderate to high yields by using easily available materials, and provides an alternative method to synthesize multi-substituted imidazole skeletons. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.04.054

文献信息

• Iron(III)-Catalyzed Synthesis of 1,2,4-Trisubstituted Imidazoles through the Reactions of Amidines and Aldehydes in Air
  作者：Xiang Liu、Dong Wang、Yongxin Chen、Dong Tang、Baohua Chen

  DOI：10.1002/adsc.201300590

  日期：2013.10.11

  AbstractA novel and efficient iron(III)‐catalyzed synthesis of 1,2,4‐trisubstituted imidazoles through the reactions of amidines and aldehydes in air has been developed. Five hydrogen dissociations involving CH and NH bond activation are realized under mild conditions in this approach. The procedure is sustainable, simple and environmentally friendly.magnified image