申请人:The University of Akron
公开号:US20140323664A1
公开(公告)日:2014-10-30
Substituted phenacyl molecules are provided and employed to create molecules and polymers/copolymers that exhibit photoresponsiveness. In some instances, the substituted phenacyl molecule is incorporated into the polymer/copolymer backbone, and photoirradiation of the polymer/copolymer causes the substituted phenacyl group to break down and the polymer/copolymer to undergo degradation. In other instances, the substituted phenacyl molecules extend as a side chain from the polymer/copolymer backbone. In yet other instances the substituted phenacyl molecules extend as a side chain from the polymer/copolymer backbone, and a drug or polymer additive is linked to the photoresponsive substituted phenacyl group such that photoirradiation releases the drug or additive. In yet other embodiments the substituted phenacyl molecules extend as a side chain from the polymer/copolymer backbone, and serve to link the polymer/copolymer to another polymer/copolymer backbone, and photoirradiation breaks the links.
提供并使用取代苯乙酰基分子来创建具有光响应性的分子和聚合物/共聚物。在某些情况下,取代苯乙酰基分子被纳入到聚合物/共聚物的骨架中,聚合物/共聚物的光照射会导致取代苯乙酰基团分解并使聚合物/共聚物发生降解。在其他情况下,取代苯乙酰基分子作为侧链从聚合物/共聚物的骨架中延伸出来。在另一些情况下,将药物或聚合物添加剂与光响应性的取代苯乙酰基团链接在一起,使光照射释放药物或添加剂。在另一些实施方式中,取代苯乙酰基分子作为侧链从聚合物/共聚物的骨架中延伸出来,用于将聚合物/共聚物与另一个聚合物/共聚物的骨架连接起来,光照射会打断这些连接。