3-(4-hydroxy benzoyl) 2-methyl 5-nitro benzofuran | 141645-17-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(4-hydroxy benzoyl) 2-methyl 5-nitro benzofuran
• 英文别名: (4-Hydroxyphenyl)(2-methyl-5-nitro-1-benzofuran-3-yl)methanone；(4-hydroxyphenyl)-(2-methyl-5-nitro-1-benzofuran-3-yl)methanone
• CAS: 141645-17-2
• 化学式: C₁₆H₁₁NO₅
• 分子量: 297.267
• InChiKey: POEQLCUBRRRNQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  96.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION
  申请人：Friesz Antal

  公开号：US20140114081A1

  公开（公告）日：2014-04-24

  The invention relates to a novel process for preparation of dronedarone (I) and pharmaceutically acceptable salts thereof where the compound of formula (II) or salt thereof is reacted with a compound of formula L-(CH 2 ) 3 —CH 3 (III), where L is a leaving group, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and the preparation thereof.

  这项发明涉及一种新型制备多奈达酮（I）及其药用可接受盐的方法，其中式化合物（II）或其盐与式化合物L-(CH2)3—CH3(III)发生反应，其中L是一个离去基团，然后分离得到的产物，并如有需要，将其转化为其药用可接受盐。该发明还涉及一些新型中间体化合物及其制备方法。
• REDUCTIVE AMINATION PROCESS FOR PREPARATION OF DRONEDARONE USING AMINE INTERMEDIARY COMPOUND
  申请人：Friesz Antal

  公开号：US20140018554A1

  公开（公告）日：2014-01-16

  The invention relates to a novel process for preparation of drohedarone of formula (I) and pharmaceutically acceptable salts thereof characterized in that a compound of formula (II) is reacted in the presence of a reductive agent with butyraldehyde and/or butanoic acid, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some hovel intermediary compounds and the preparation thereof.

  这项发明涉及一种新型制备式（I）的多赫达鲁酮及其药用可接受盐的方法，其特征在于在还原剂存在下，化合物式（II）与丁醛和/或丁酸反应，并分离得到的产物，如有需要，将其转化为药用可接受盐。该发明还涉及一些新颖的中间体化合物及其制备方法。
• PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP
  申请人：SANOFI

  公开号：US20150005515A1

  公开（公告）日：2015-01-01

  The invention relates to a process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof characterized in that from the compound of formula (II). the hydroxyl group is removed, and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof.

  本发明涉及一种制备式（I）的多奈达鲁酮及其药用可接受盐的过程，其特征在于从式（II）的化合物中去除羟基，隔离所得产物，并如有需要将其转化为药用可接受的盐。
• PROCESS FOR PREPARATION OF DRONEDARONE BY THE USE OF DIBUTYLAMINOPROPANOL REAGENT
  申请人：SANOFI

  公开号：US20160075673A1

  公开（公告）日：2016-03-17

  The invention relates to a novel process for preparation of dronedarone of formula (I) and pharmaceutically acceptable salts thereof, characterized in that a compound of formula (II)—where L is leaving group—is reacted with compound of formula (III) and the obtained product is isolated and, if desired, converted into a pharmaceutically acceptable salt thereof.

  本发明涉及一种制备式（I）的多内酯及其药学上可接受的盐的新工艺，其特征在于将式（II）的化合物（其中L为离去基团）与式（III）的化合物反应，得到的产物被分离，并在需要时转化为其药学上可接受的盐。
• US5223510A
  申请人：——

  公开号：US5223510A

  公开（公告）日：1993-06-29