1-(3-(Hydroxymethyl)phenyl)propan-1-one | 125604-07-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(3-(Hydroxymethyl)phenyl)propan-1-one
• 英文别名: 1-[3-(hydroxymethyl)phenyl]propan-1-one
• CAS: 125604-07-1
• 化学式: C₁₀H₁₂O₂
• 分子量: 164.2
• InChiKey: MQHRSHGUGYCQDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Substituted n-pentanamide compounds, preparation method and the use thereof
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：US20140046074A1

  公开（公告）日：2014-02-13

  The present invention relates to a (2R, 3R)-3-(3-substituted phenyl)-2-methyl n-pentanamide compounds as shown in the formula I and the preparation method thereof, wherein, the substituents are as defined in the specification, the present invention further relates to a use of the above compounds for the preparation of tapentadol II or its pharmaceutically acceptable salt, and the intermediates involved in the preparation process.

  本发明涉及一种如化学式I所示的(2R, 3R)-3-(3-取代苯基)-2-甲基n-戊酰胺化合物及其制备方法，其中，取代基如规范中所定义，本发明还涉及上述化合物用于制备tapentadol II或其药用可接受盐，以及制备过程中涉及的中间体。
• Alpha- and beta-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
  申请人：Vazquez L. Michael

  公开号：US20070078173A1

  公开（公告）日：2007-04-05

  α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

  α-和β-氨基酸羟乙基氨磺酰胺化合物可作为逆转录病毒蛋白酶抑制剂，特别是作为HIV蛋白酶的抑制剂。
• SUBSTITUTED N-PENTANAMIDE COMPOUNDS, PREPARATION METHOD AND THE USE THEREOF
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：US20160102047A1

  公开（公告）日：2016-04-14

  The present invention relates to a (2R,3R)-3-(3-substituted phenyl)-2-methyl n-pentanamide compounds as shown in the formula I and the preparation method thereof, wherein, the substituents are as defined in the specification, the present invention further relates to a use of the above compounds for the preparation of tapentadol II or its pharmaceutically acceptable salt, and the intermediates involved in the preparation process

  本发明涉及一种(2R,3R)-3-(3-取代苯基)-2-甲基n-戊酰胺化合物，如公式I所示，以及其制备方法，其中，取代基如规范中所定义，本发明还涉及上述化合物用于制备tapentadol II或其药学上可接受的盐，以及制备过程中涉及的中间体。
• GAMMA-RAY STABILIZER AND THERMOPLASTIC POLYMER COMPOSITION CONTAINING THE SAME
  申请人：Teijin Chemicals, Ltd.

  公开号：EP1004621B1

  公开（公告）日：2004-09-15
• US6485657B1
  申请人：——

  公开号：US6485657B1

  公开（公告）日：2002-11-26