1-Ethyl-2'-deoxyguanosin | 50704-47-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 1-Ethyl-2'-deoxyguanosin
• 英文别名: 2'-deoxy-1-ethylguanosine；1-ethyl-2'-deoxy-guanosine；1-Ethyl-deoxyguanosine；2-amino-1-ethyl-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-one
• CAS: 50704-47-7
• 化学式: C₁₂H₁₇N₅O₄
• 分子量: 295.298
• InChiKey: IXKRKZRXWXOKBH-XLPZGREQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3',5'-di-O-acetyl-2'-deoxy-N2-[(dimethylamino)methylene]-1-ethylguanosine 在 氨 作用下， 以 甲醇 、 水 为溶剂， 反应 96.0h， 以75%的产率得到1-Ethyl-2'-deoxyguanosin
  参考文献：
  名称：

  核苷酸。第LXXVIII部分

  摘要：

  几个Ñ（羟基烷基）-2,4-二硝基苯胺转化成它们的亚磷酰胺（参见5和6在方案1）鉴于它们作为荧光猝灭剂的使用，和改性的2-氨基苯甲酰胺（参见图9，10，18，和19在方案1中）在模型反应施加为荧光团，以确定3'-ABA的相对荧光量子产率和5'-DNP-3'-ABA共轭物（ABA =氨基苯甲酰胺，DNP =二硝基苯胺）。胸苷用N-（2-氯乙基）-2-，4-二硝基苯胺（24）烷基化，得到25，然后将其进一步修饰为结构单元27和28（方案3）。29中的2-氨基通过重氮化转化为2-氟肌苷衍生物30，用作在嘧啶核上进行数个反应的起始原料（→ 31、33和35；方案4）。3'，5'-二-O-乙酰基-2'-脱氧-N 2 -[（（二甲基氨基）亚甲基]鸟苷（37）被甲基和乙基碘化物优先在N（1）分别烷基化至43和44，并且类似地反应ñ - （2-氯乙基）-2,4-二硝基苯胺（24），以38和N-（2-碘乙基

  DOI：

  10.1002/hlca.201000253

文献信息

• Multifunctional ligand system for cell-specific transfer of nucleic acid
  申请人：HOECHST AKTIENGESELLSCHAFT

  公开号：EP0846772A1

  公开（公告）日：1998-06-10

  The invention relates to a multifunctional ligand system that is not immunogenic and that carries out cell-specific transfer of nucleotide sequences. The system comprises at least one target cell-specific ligand, at least one linker and at least one gene construct-specific ligand, with the gene construct-specific ligand advantageously comprising an antibody, or a part thereof, which binds directly or indirectly to the gene construct. The invention also relates to ligand systems for preparing a pharmaceutical or a vaccine for the treatment or prevention of a disease of the skin, of the mucous membranes, of the nervous system, of the internal organs, of blood coagulation, of the hemopoietic system, of the immune system, of the musculature, of the sustentacular tissue or of the joints.

  本发明涉及一种多功能配体系统，该系统无免疫原性，可进行核苷酸序列的细胞特异性转移。该系统包括至少一种靶细胞特异性配体、至少一种连接体和至少一种基因构建体特异性配体，其中基因构建体特异性配体有利地包括直接或间接与基因构建体结合的抗体或其一部分。本发明还涉及配体系统，用于制备治疗或预防皮肤、粘膜、神经系统、内脏器官、血液凝固、造血系统、免疫系统、肌肉组织、软组织或关节疾病的药物或疫苗。
• Novel complex-forming proteins
  申请人：——

  公开号：US20030054409A1

  公开（公告）日：2003-03-20

  The invention relates to a complex of specifically complex-forming proteins which are not naturally occurring, comprising the following components: a) at least one ligand specific for a target structure, b) at least one protein comprising a mutated dimerization domain, the mutated dimerization domain having been derived by mutation of a naturally occurring dimerization domain, it being possible for this mutated dimerization domain to interact specifically with component c) and the component b) being connected covalently to the component a), c) at least one protein comprising a mutated dimerization domain, the mutated dimerization domain having been derived by mutation of a naturally occurring dimerization domain, it being possible for this mutated dimerization domain to interact specifically with component b) and the component c) is linked covalently to the component d), and d) at least one effector. In addition, the invention relates to the use and preparation of these complexes, and to nucleic acid constructs coding for the proteins mentioned and use thereof.

  本发明涉及一种非天然存在的特异性复合物形成蛋白的复合物，由以下组分组成：a) 至少一种针对目标结构的特异性配体； b) 至少一种包含突变二聚化结构域的蛋白质，该突变二聚化结构域是由天然存在的二聚化结构域突变而来，该突变二聚化结构域可与成分 c) 发生特异性相互作用，成分 b) 与成分 a) 共价连接、c) 至少一种包含突变二聚化结构域的蛋白质，该突变二聚化结构域是通过突变天然存在的二聚化结构域而得到的，该突变二聚化结构域可与组分 b) 发生特异性相互作用，组分 c) 与组分 d) 共价连接；以及 d) 至少一种效应物。此外，本发明还涉及这些复合物的使用和制备，以及编码所述蛋白质的核酸构建体及其使用。
• Single-chain multiple antigen-binding molecule, its preparation and use
  申请人：Kontermann Roland

  公开号：US20050004352A1

  公开（公告）日：2005-01-06

  The present invention relates to a single-chain, multiple antigen-binding molecule with diverse variable domains of a heavy and of a light chain of an immunoglobulin, which are connected in the form of a VH-VL construct, which are in turn connected together via a peptide, and to the preparation and use thereof as pharmaceutical or diagnostic aid.

  本发明涉及一种单链多抗原结合分子，该分子具有免疫球蛋白重链和轻链的多种可变结构域，这些结构域以 VH-VL 构建形式连接在一起，而这些结构域又通过肽连接在一起，本发明还涉及其制备和用作药物或诊断辅助工具。
• Single-chain Multiple Antigen-binding Molecule, Its Preparation and Use
  申请人：Kontermann Roland

  公开号：US20090326206A1

  公开（公告）日：2009-12-31

  The present invention relates to a single-chain, multiple antigen-binding molecule with diverse variable domains of a heavy and of a light chain of an immunoglobulin, which are connected in the form of a VH-VL construct, which are in turn connected together via a peptide, and to the preparation and use thereof as pharmaceutical or diagnostic aid.
• US6582918B2
  申请人：——

  公开号：US6582918B2

  公开（公告）日：2003-06-24