5-bromo-1,3-dihydro-N,N,1,1-tetramethyl-6-isobenzofuranamine | 156054-97-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: 5-bromo-1,3-dihydro-N,N,1,1-tetramethyl-6-isobenzofuranamine
• CAS: 156054-97-6
• 化学式: C₁₂H₁₆BrNO
• 分子量: 270.169
• InChiKey: ZXAPBEBYRBUDHZ-UHFFFAOYSA-N

物化性质

• 沸点：
  333.1±42.0 °C(predicted)
• 密度：
  1.336±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  丙酰氯 、 5-bromo-1,3-dihydro-N,N,1,1-tetramethyl-6-isobenzofuranamine 在 正丁基锂 作用下， 生成 1,3-dihydro-1,1-dimethyl-6-dimethylamino-α-ethyl-5-isobenzofuranmethanol
  参考文献：
  名称：

  Synthesis of Isobenzofuran Derivatives as heterocyclic analogues of the herbicidesindone B

  摘要：

  The target compounds 21-27 were synthesized via bromination of the N,N,1,1-tetramethylisobenzofuranamines 13, 15 and 16, subsequent bromine-lithium exchange and reaction with propanal or propanoyl chloride, respectively. In the course of some model reactions undertaken to test a synthetic strategy based on directed ortho-lithiation governed by the dimethylamino-group a useful synthesis of the ketone 3 was developed.

  DOI：

  10.1002/prac.19943360411
• 作为产物：
  描述：

  1,3-Dihydro-N,N,1,1-tetramethyl-6-isobenzofuranamin 在 溴 作用下， 以 甲醇 为溶剂， 反应 0.67h， 以85%的产率得到5-bromo-1,3-dihydro-N,N,1,1-tetramethyl-6-isobenzofuranamine
  参考文献：
  名称：

  Synthesis of Isobenzofuran Derivatives as heterocyclic analogues of the herbicidesindone B

  摘要：

  The target compounds 21-27 were synthesized via bromination of the N,N,1,1-tetramethylisobenzofuranamines 13, 15 and 16, subsequent bromine-lithium exchange and reaction with propanal or propanoyl chloride, respectively. In the course of some model reactions undertaken to test a synthetic strategy based on directed ortho-lithiation governed by the dimethylamino-group a useful synthesis of the ketone 3 was developed.

  DOI：

  10.1002/prac.19943360411