(S)-4-Benzyl-3-isopropyl-1-(4-methoxy-benzyl)-piperazine-2,5-dione | 479681-27-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-4-Benzyl-3-isopropyl-1-(4-methoxy-benzyl)-piperazine-2,5-dione
• CAS: 479681-27-1
• 化学式: C₂₂H₂₆N₂O₃
• 分子量: 366.46
• InChiKey: ALSJHJCVZVCFJC-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.09
• 重原子数：
  27.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  49.85
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (S)-4-Benzyl-3-isopropyl-1-(4-methoxy-benzyl)-piperazine-2,5-dione 在 正丁基锂 、 ammonium cerium(IV) nitrate 作用下， 以 四氢呋喃 、 正己烷 、 水 、 乙腈 为溶剂， 生成 (3R,6S)-1-benzyl-3-[[4-[[(2R,5S)-4-benzyl-3,6-dioxo-5-propan-2-ylpiperazin-2-yl]methyl]phenyl]methyl]-6-propan-2-ylpiperazine-2,5-dione
  参考文献：
  名称：

  Homochiral Supramolecular Polymerization of an “S”-Shaped Chiral Monomer:  Translation of Optical Purity into Molecular Weight Distribution

  摘要：

  An "S"-shaped chiral motif of a p-xylylene-bridged bis(cyclic dipeptide) (1), having four hydrogen-bonding amide functionalities, formed a homochiral supramolecular polymer in solution. X-ray crystallography of a slightly modified version of 1 for an enhanced crystallinity showed one-dimensional columnar assemblies via four double hydrogen-bonding interactions. Model studies with half-protected analogues of 1 indicated a nearly perfect enantioselectivity in hydrogen-bonding dimerization. When 1 was not racemic but enriched in either of the enantiomers, a supramolecular polymer with a bimodal molecular weight distribution resulted, due to the formation of two homochiral polymers with different molecular weights. By taking advantage of this, separation of optically pure 1 from an enantiomerically unbalanced mixture was possible by means of size-exclusion chromatography.

  DOI：

  10.1021/ja028403h
• 作为产物：
  描述：

  (S)-3-异丙基-2,5-哌嗪二酮 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 (S)-4-Benzyl-3-isopropyl-1-(4-methoxy-benzyl)-piperazine-2,5-dione
  参考文献：
  名称：

  Homochiral Supramolecular Polymerization of an “S”-Shaped Chiral Monomer:  Translation of Optical Purity into Molecular Weight Distribution

  摘要：

  An "S"-shaped chiral motif of a p-xylylene-bridged bis(cyclic dipeptide) (1), having four hydrogen-bonding amide functionalities, formed a homochiral supramolecular polymer in solution. X-ray crystallography of a slightly modified version of 1 for an enhanced crystallinity showed one-dimensional columnar assemblies via four double hydrogen-bonding interactions. Model studies with half-protected analogues of 1 indicated a nearly perfect enantioselectivity in hydrogen-bonding dimerization. When 1 was not racemic but enriched in either of the enantiomers, a supramolecular polymer with a bimodal molecular weight distribution resulted, due to the formation of two homochiral polymers with different molecular weights. By taking advantage of this, separation of optically pure 1 from an enantiomerically unbalanced mixture was possible by means of size-exclusion chromatography.

  DOI：

  10.1021/ja028403h