1,1,2-Trichloropropan-1-ol | 230950-79-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代醇
• 英文名称: 1,1,2-Trichloropropan-1-ol
• CAS: 230950-79-5
• 化学式: C₃H₅Cl₃O
• 分子量: 163.43
• InChiKey: GHFQLVDCWGZPGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] CONVERSION OF A MULTIHYDROXYLATED-ALIPHATIC HYDROCARBON OR ESTER THEREOF TO A CHLOROHYDRIN<br/>[FR] CONVERSION D'UN HYDROCARBURE ALIPHATIQUE MULTIHYDROXYLE OU L'UN DE SES ESTERS EN CHLOROHYDRINE
  申请人：DOW GLOBAL TECHNOLOGIES INC

  公开号：WO2006020234A1

  公开（公告）日：2006-02-23

  The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts. In addition, certain catalysts of the present invention may be used in the present process at superatmospheric, atmospheric and subatmospheric pressure conditions with improved results.

  本发明涉及一种将多羟基脂肪烃或其酯转化为氯水合物的方法，通过将多羟基脂肪烃或其酯起始物料与氯化氢的超大气分压源接触足够的时间和适当的温度，其中这种接触步骤在没有实质性去除水的情况下进行，以生产所需的氯水合物产品；所述所需产品或产品可以高产率地制备，而几乎不形成不需要的过氯化副产物。此外，本发明的某些催化剂可以在超大气压、大气压和次大气压条件下用于本方法，取得改进的结果。
• METHOD FOR PRODUCING CYCLIC CARBONATE
  申请人：NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

  公开号：US20160145234A1

  公开（公告）日：2016-05-26

  Provided is a method for producing a cyclic carbonate obtained by reacting epoxide and carbon dioxide, the method being capable of efficiently producing a cyclic carbonate at a high conversion rate and a high yield, in which degradation of the catalyst over time is suppressed and catalytic activity hardly decreases. A method for producing a cyclic carbonate by reacting epoxide and carbon dioxide in the presence of a quaternary onium salt selected from the group consisting of a quaternary ammonium salt having a halogenated anion as a counter ion and a quaternary phosphonium salt having a halogenated anion as a counter ion, or in the presence of a solid catalyst obtained by immobilizing the quaternary onium salt onto a carrier, wherein an organohalogen compound containing at least one halogen atom in one molecule is added to the reaction system.

  提供了一种生产环状碳酸酯的方法，该方法通过反应环氧化物和二氧化碳获得，能够高效地以高转化率和高产率生产环状碳酸酯，同时抑制催化剂随时间降解并且催化活性几乎不会下降。在存在从属于具有卤素阴离子作为对离子的季铵盐和具有卤素阴离子作为对离子的季膦盐中选择的季铵盐，或者存在通过将季铵盐固定在载体上而获得的固体催化剂的情况下，通过在反应体系中添加含有至少一个卤素原子的有机卤素化合物来生产环状碳酸酯的方法。
• Verfahren und Reagenz zur Aktivierung der Cholesterinesterase
  申请人：BOEHRINGER MANNHEIM GMBH

  公开号：EP0016946A1

  公开（公告）日：1980-10-15

  Die Aktivierung der Cholesterinesterase in ionenhaltiger Lösung erfolgt durch Zusatz von einem Polyäthoxyäther oder -ester oder/und einer Gallensäureverbindung und/oder Salzen von Fettsäuren mit 6 bis 10 Kohlenstoffatomen in Kombination mit einem synergistisch wirkenden Alkohol, der aus den geradkettigen, verzweigten oder cyclischen aliphatischen Alkoholen mit 5 bis 12 Kohlenstoffatomen, gegebenenfalls halogensubstituierten, aromatischen Alkoholen und den mit mehreren Halogenatomen substituierten aliphatischen Alkoholen mit 1 bis 3 Kohlenstoffatomen ausgewählt ist.

  在含离子的溶液中，加入聚乙氧基醚或酯和/或胆汁酸化合物和/或 6 至 10 个碳原子的脂肪酸盐，再加入一种增效醇，这种增效醇选自 5 至 12 个碳原子的直链、支链或环状脂肪醇，可选择卤素取代的芳香醇和 1 至 3 个碳原子被多个卤素原子取代的脂肪醇，从而激活胆固醇酯化酶。
• Conversion of a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin
  申请人：DOW GLOBAL TECHNOLOGIES INC.

  公开号：EP2174925A1

  公开（公告）日：2010-04-14

  A process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts. In addition, certain catalysts of the present invention may be used in the present process at superatmospheric, atmospheric and subatmospheric pressure conditions with improved results.

  一种将多羟基化脂肪烃或其酯转化为氯醇的工艺，其方法是将多羟基化脂肪烃或其酯起始原料与超大气压分压的氯化氢源在足够的时间和足够的温度下进行接触，并且在不大量脱水的情况下进行这种收缩步骤，以生产所需的氯醇产品；其中可以高产率生产所需的一种或多种产品，而不会大量形成不需要的过氯副产品。此外，本发明的某些催化剂可在超大气压、大气压和亚大气压条件下用于本发明的工艺中，并取得更好的效果。
• Conversion of a multihydroxylated aliphatic hydrocarbon or ester thereof to a chlorohydrin
  申请人：DOW GLOBAL TECHNOLOGIES INC.

  公开号：EP2181979A1

  公开（公告）日：2010-05-05

  A process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts. In addition, certain catalysts of the present invention may be used in the present process at superatmospheric, atmospheric and subatmospheric pressure conditions with improved results.

  一种将多羟基化脂肪烃或其酯转化为氯醇的工艺，其方法是将多羟基化脂肪烃或其酯起始原料与超大气压分压的氯化氢源在足够的时间和足够的温度下进行接触，并且在不大量脱水的情况下进行这种收缩步骤，以生产所需的氯醇产品；其中可以高产率生产所需的一种或多种产品，而不会大量形成不需要的过氯副产品。此外，本发明的某些催化剂可在超大气压、大气压和亚大气压条件下用于本发明的工艺中，并取得更好的效果。