6,7-dimethoxy-3,4-dihydro-naphthalene-1,2-dicarboxylic acid-anhydride | 102313-04-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并呋喃类
• 英文名称: 6,7-dimethoxy-3,4-dihydro-naphthalene-1,2-dicarboxylic acid-anhydride
• 英文别名: 6,7-Dimethoxy-3,4-dihydro-naphthalin-1,2-dicarbonsaeure-anhydrid；7,8-Dimethoxy-4,5-dihydrobenzo[e][2]benzofuran-1,3-dione
• CAS: 102313-04-2
• 化学式: C₁₄H₁₂O₅
• 分子量: 260.246
• InChiKey: FZWDVQUVSAINPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6,7-dimethoxy-3,4-dihydro-naphthalene-1,2-dicarboxylic acid-anhydride 在 1,4-二氧六环 、 氢溴酸 、 溶剂黄146 、 铂 作用下， 生成 (+/-)-6,7-dihydroxy-1,2,3,4,9,10-hexahydro-phenanthrene-4ar,10ac-dicarboxylic acid-anhydride
  参考文献：
  名称：

  The Synthesis of Phenanthrene and Hydrophenanthrene Derivatives. IV. Hydroxylated Compounds

  摘要：

  DOI：

  10.1021/ja01302a068
• 作为产物：
  描述：

  6,7-dimethoxy-3,4-dihydro-naphthalene-1,2-dicarboxylic acid diethyl ester 在 氢氧化钾 、 乙酸酐 作用下， 生成 6,7-dimethoxy-3,4-dihydro-naphthalene-1,2-dicarboxylic acid-anhydride
  参考文献：
  名称：

  817. 2：3-二羟基萘的某些衍生物

  摘要：

  DOI：

  10.1039/jr9560004252

文献信息

• Glyoxylate Cyclizations. Methoxybenzsuberenes¹
  作者：E. C. Horning、John Koo

  DOI：10.1021/ja01156a110

  日期：1951.12
• Progressive ataxia and seizures in a Cocker Spaniel: a new type of neurodegenerative disease with novel intra-neuronal inclusions
  作者：RD Jolly、I Schraa、TR Halsey

  DOI：10.1080/00480169.2002.36312

  日期：2002.10

  AIMS: To describe the histopathological lesions of a new canine disease characterised by progressive ataxia, head tremor and seizures, and to deduce the cause of the lesions.METHODS: Formalin-fixed tissues were processed into paraffin wax and epoxy resin for light and transmission electron microscopy of variously stained tissue sections.RESULTS: Significant lesions relevant to the disease were found only in the brain. They consisted of hypoplasia of the cerebellum and the presence of large pale inclusions in the perikaryon of neurons in the neocortex and in macrophages. The inclusion material was not compartmentalised and did not stain for carbohydrate, mucopolysaccharide or lipid. This material displaced nuclei to the periphery of the cells where they were seen as basophilic distorted crescent-shaped structures.CONCLUSIONS: The inclusions were probably made of polymerised protein similar, though not identical, to those of Pick, Lewy and Collins bodies that characterise a variety of chronic neurodegenerative diseases of humans. A genetic basis to this disease was considered probable.
• US5187285A
  申请人：——

  公开号：US5187285A

  公开（公告）日：1993-02-16
• The Synthesis of Phenanthrene and Hydrophenanthrene Derivatives. IV. Hydroxylated Compounds
  作者：L. F. Fieser、E. B. Hershberg

  DOI：10.1021/ja01302a068

  日期：1936.11
• 817. Some derivatives of 2 : 3-dihydroxynaphthalene
  作者：F. H. Howell、D. A. H. Taylor

  DOI：10.1039/jr9560004252

  日期：——