alpha-D-Mannopyranose, 2-(acetylamino)-2-deoxy-, 1-(dihydrogen phosphate) | 46972-60-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: alpha-D-Mannopyranose, 2-(acetylamino)-2-deoxy-, 1-(dihydrogen phosphate)
• 英文别名: [(2R,3S,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl] dihydrogen phosphate
• CAS: 46972-60-5
• 化学式: C₈H₁₆NO₉P
• 分子量: 301.19
• InChiKey: FZLJPEPAYPUMMR-OZRXBMAMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  166
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• [EN] CARBOCYCLIC DERIVATIVES AND CONJUGATED DERIVATIVES THEREOF, AND THEIR USE IN VACCINES<br/>[FR] DÉRIVÉS CARBOCYCLIQUES ET LEURS DÉRIVÉS CONJUGUÉS, ET LEUR UTILISATION DANS DES VACCINS
  申请人：GLAXOSMITHKLINE BIOLOGICALS SA

  公开号：WO2020182635A1

  公开（公告）日：2020-09-17

  The invention is in the field of vaccines and relates to oligomers having a selected degree of polymerization, obtained by connecting together a number of carbocyclic repeating units, and to conjugated derivatives thereof. The oligomers and conjugated derivatives thereof of the invention also have a selected degree of acetylation. The derivatives of the invention are useful for the preparation of immunogenic compositions, e.g. in the form of a vaccine.

  这项发明涉及疫苗领域，涉及具有选定聚合度的寡聚体，通过连接一定数量的碳环重复单元而获得，并涉及其共轭衍生物。该发明的寡聚体及其共轭衍生物还具有选定的乙酰化程度。该发明的衍生物可用于制备免疫原性组合物，例如疫苗形式。
• [EN] PENTAVALENT VACCINE AGAINST NEISSERIA MENINGITIDIS COMPRISING A SYNTHETIC MEN A ANTIGEN<br/>[FR] VACCIN PENTAVALENT CONTRE NEISSERA MENINGITIDIS COMPRENANT UN ANTIGÈNE SYNTHÉTIQUE MEN A
  申请人：GLAXOSMITHKLINE BIOLOGICALS SA

  公开号：WO2022043238A1

  公开（公告）日：2022-03-03

  The inventors have identified a combined vaccine for immunisation against bacterial meningitis caused by multiple pathogens.

  发明家们已经确定了一种联合疫苗，用于预防由多种病原体引起的细菌性脑膜炎。
• CARBOCYCLIC DERIVATIVES AND CONJUGATED DERIVATIVES THEREOF, AND THEIR USE IN VACCINES
  申请人：GlaxoSmithKline Biologicals S.A.

  公开号：EP3934696A1

  公开（公告）日：2022-01-12