N-(4-chlorophenyl)-5-{[2-({(2R,5R)-2-[(dimethylamino)methyl]-5-methylmorpholin-4-yl}carbonyl)pyridin-4-yl]oxy}-1-methyl-1H-benzimidazol-2-amine | 611223-74-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(4-chlorophenyl)-5-{[2-({(2R,5R)-2-[(dimethylamino)methyl]-5-methylmorpholin-4-yl}carbonyl)pyridin-4-yl]oxy}-1-methyl-1H-benzimidazol-2-amine
• 英文别名: [4-[2-(4-chloroanilino)-1-methylbenzimidazol-5-yl]oxypyridin-2-yl]-[(2R,5R)-2-[(dimethylamino)methyl]-5-methylmorpholin-4-yl]methanone
• CAS: 611223-74-6
• 化学式: C₂₈H₃₁ClN₆O₃
• 分子量: 535.046
• InChiKey: PEDQGMMKRHVJEZ-WZONZLPQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  84.8
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• NITROXIDE CONTAINING ELECTRODE MATERIALS FOR SECONDARY BATTERIES
  申请人：Nesvadba Peter

  公开号：US20100181527A1

  公开（公告）日：2010-07-22

  This invention relates to a stable secondary battery utilizing as active principle the oxidation and reduction cycle of a sterically hindered nitroxide radical, a sterically hindered oxoammonium cation, a sterically hindered hydroxylamine or a sterically hindered aminoxide anion containing a piperazin-2,6-dione, a piperazin-2-one or morpholin-2-one structural unit. Further aspects of the invention are a method for providing such a secondary battery, the use of the respective compounds as active elements in secondary batteries and selected novel compounds.

  本发明涉及一种稳定的二次电池，利用空间位阻的亚硝基自由基、空间位阻的氧代铵阳离子、空间位阻的羟胺或空间位阻的氨氧阴离子，其中包含哌嗪-2,6-二酮、哌嗪-2-酮或吗啉-2-酮结构单元的氧化还原循环作为活性原理。发明的其他方面包括提供这种二次电池的方法，使用相应化合物作为二次电池中的活性元素以及选择的新化合物。
• SUBSTITUTED BENZ-AZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE
  申请人：Amiri Payman

  公开号：US20100196368A1

  公开（公告）日：2010-08-05

  New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

  本发明提供了新的取代苯并唑化合物、组合物和抑制人类或动物主体中Raf激酶活性的方法。新的化合物组成物可以单独使用或与至少一种其他药物联合使用，用于治疗Raf激酶介导的疾病，如癌症。
• SUBSTITUTED BENZAZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE
  申请人：Amiri Payman

  公开号：US20120288501A1

  公开（公告）日：2012-11-15

  New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.

  提供了新的取代苯唑化合物、组合物和抑制人类或动物主体中Raf激酶活性的方法。这些新的化合物组合物可以单独使用或与至少一种额外的药物联合使用，用于治疗Raf激酶介导的疾病，如癌症。
• SUBSTITUTED BENZAZOLES AND USE THEREOF AS RAF KINASE INHIBITORS
  申请人：Novartis Vaccines and Diagnostics, Inc.

  公开号：EP1499311B1

  公开（公告）日：2009-11-04
• US7071216B2
  申请人：——

  公开号：US7071216B2

  公开（公告）日：2006-07-04