p-Nitro-N-α-benzyloxycarbonyl-L-citrullinat | 6464-62-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: p-Nitro-N-α-benzyloxycarbonyl-L-citrullinat
• 英文别名: N-Benzyloxycarbonyl-citrullin-(4-nitro-phenylester)；(4-nitrophenyl) (2S)-5-(carbamoylamino)-2-(phenylmethoxycarbonylamino)pentanoate
• CAS: 6464-62-6
• 化学式: C₂₀H₂₂N₄O₇
• 分子量: 430.417
• InChiKey: YMWVPKHGQABBBV-KRWDZBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  166
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  p-Nitro-N-α-benzyloxycarbonyl-L-citrullinat 在 钯 N-甲基吗啉 、 氢气 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 24.5h， 生成 (S)-((S)-2-Amino-5-ureido-pentanoylamino)-[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-yl]-acetic acid; compound with trifluoro-acetic acid
  参考文献：
  名称：

  Design of anticandidal agents: synthesis and biological properties of analogs of polyoxin L

  摘要：

  Six analogues of polyoxin L were synthesized from uridine. All of these analogues inhibited chitin synthetase from Candida albicans. Derivatization of the amine terminus of the polyoxin analogues resulted in loss of activity, and analogues containing aromatic amino acid residues were the most efficient inhibitors of chitin synthetase. The concentration of tryptophanyl uracil polyoxin C, 8, which caused 50% inhibition of chitin synthetase activity, was 1.6 X 10(-6) M. This was virtually identical with the activity found for polyoxin D. None of the inhibitors effectively competed with the entry of (Met)3 into C. albicans. All of the analogues caused severe morphological distortions of the yeast in culture, and a number of analogues killed C. albicans at millimolar concentrations. The results suggest that chitin synthetase inhibitors may have potential as anticandidal drugs.

  DOI：

  10.1021/jm00364a030