5-methoxy-1H-pyrazolo[3,4-b]pyrazine | 116527-53-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并[3,4-b]吡嗪
• 英文名称: 5-methoxy-1H-pyrazolo[3,4-b]pyrazine
• CAS: 116527-53-8
• 化学式: C₆H₆N₄O
• mdl: MFCD18809797
• 分子量: 150.14
• InChiKey: YMRINHUBBHWCIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  63.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] SHP2 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE SHP2 ET LEURS UTILISATIONS
  申请人：SYNBLIA THERAPEUTICS INC

  公开号：WO2021061515A1

  公开（公告）日：2021-04-01

  Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.

  公开了作为蛋白酪氨酸磷酸酶SHP2抑制剂的化合物1的化合物。还公开了包括化合物1的药物组合物、这些化合物的合成方法、使用这些化合物或含有这些化合物的组合物进行治疗与SHP2异常活性相关的疾病，如癌症的方法。
• SHP2 inhibitors and uses thereof
  申请人：SYNBLia Therapeutics, Inc.

  公开号：US10561655B2

  公开（公告）日：2020-02-18

  Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.

  本发明公开了作为蛋白酪氨酸磷酸酶 SHP2 抑制剂的式 1 化合物。还公开了包含式 1 化合物的药物组合物、合成这些化合物的方法、使用这些化合物或含有这些化合物的组合物治疗与 SHP2 活性异常有关的疾病（如癌症）的方法。
• SHP2 INHIBITORS AND USES THEREOF
  申请人：SYNBLia Therapeutics, Inc.

  公开号：US20190290649A1

  公开（公告）日：2019-09-26

  Compounds of Formula 1 as inhibitors of protein tyrosine phosphatase SHP2 are disclosed. The pharmaceutical compositions comprising compounds of Formula 1, methods of synthesis of these compounds, methods of treatment for diseases associated with the aberrant activity of SHP2 such as cancer using these compounds or compositions containing these compounds are also disclosed.