(1ar)-1,1a,2,3,4,5,6,6a-octahydro-2c,6c-ethano-cycloprop[f]indene-1ξ,7anti,8anti-tricarboxylic acid-7,8-anhydride-1-methyl ester | 132346-40-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1ar)-1,1a,2,3,4,5,6,6a-octahydro-2c,6c-ethano-cycloprop[f]indene-1ξ,7anti,8anti-tricarboxylic acid-7,8-anhydride-1-methyl ester
• 英文别名: (1ar)-1,1a,2,3,4,5,6,6a-octahydro-2c,6c-ethano-cycloprop[f]indene-1ξ,7anti,8anti-tricarboxylic acid-7,8-anhydride-1-methyl ester；(1ar)-1,1a,2,3,4,5,6,6a-Octahydro-2c,6c-aethano-cycloprop[f]inden-1ξ,7anti,8anti-tricarbonsaeure-7,8-anhydrid-1-methylester
• CAS: 132346-40-8
• 化学式: C₁₆H₁₆O₅
• 分子量: 288.3
• InChiKey: AANUUHBVLNUMBD-YEJGXGRLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.08
• 重原子数：
  21.0
• 可旋转键数：
  1.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  69.67
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  1,4-二苯基-1,3丁二烯 、 (1ar)-1,1a,2,3,4,5,6,6a-octahydro-2c,6c-ethano-cycloprop[f]indene-1ξ,7anti,8anti-tricarboxylic acid-7,8-anhydride-1-methyl ester 生成 methyl azulene-6-carboxylate
  参考文献：
  名称：

  Alder et al., Justus Liebigs Annalen der Chemie, 1959, vol. 627, p. 59,72

  摘要：

  DOI：
• 作为产物：
  描述：

  茚满 、 重氮乙酸甲酯 生成 (1ar)-1,1a,2,3,4,5,6,6a-octahydro-2c,6c-ethano-cycloprop[f]indene-1ξ,7anti,8anti-tricarboxylic acid-7,8-anhydride-1-methyl ester 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Alder et al., Justus Liebigs Annalen der Chemie, 1959, vol. 627, p. 59,72

  摘要：

  DOI：

文献信息

• Peritoneal dialysis in an infant with Type 1 diabetes and hyperosmolar coma
  作者：G. Multari、B. Werner、M. Cervoni、R. Lubrano、F. Costantino、V. Demiraj、P. Pozzilli

  DOI：10.1007/bf03343822

  日期：2001.2

  Hyperosmolar coma which is characterized by severe hyperglycemia in absence of chetosis is very rare in pediatric age with only 11 cases reported in the literature. The outcome of the condition is usually poor with mental retardation being the most common event. Here a case of hyperosmolar coma is described in a female of three months of age who was treated with peritoneal dialysis 11 hours after admittance to hospital. This female patient has been receiving insulin from three months of age and today at the age of 10 years she leads a normal life despite being on insulin therapy. A very low level of C-peptide (<0.3 ng/ml) clearly confirms she is affected by Type 1 diabetes. To our knowledge this is the first case report of hyperosmolar coma in a neonate with Type 1. diabetes who survived this condition without late neurological consequences. (C)2001. Editrice Kurtis.