| 1565621-86-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1565621-86-4
• 化学式: C₁₄H₁₁ClN₂O₃
• 分子量: 290.706
• InChiKey: ZYXOBFGDZJJECK-WUKNDPDISA-N

反应信息

• 作为反应物：
  描述：

  在 potassium hydroxide 、 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 72.5h， 生成
  参考文献：
  名称：

  Antibacterial and free radical scavenging potential of synthesized 7-hydroxy-2-aryl-6-aryldiazenyl-4H-chromen-4-ones

  摘要：

  A series of 7-hydroxy-2-aryl-6-aryldiazenyl-4H-chromen-4-one derivatives (6a-m) was synthesized in quantitative yields and their structures were corroborated on the basis of FT-IR, H-1, C-13 NMR, ESI-MS, and elemental analysis data. The synthesized compounds were screened for in vitro antibacterial activities against a representative panel of Gram-positive and Gram-negative bacteria, as well as to evaluate their antioxidant potential using DPPH assay method. Bio-evaluation studies revealed that compounds 6c, 6d, 6e, 6j, and 6l exhibited moderate to good antibacterial activity against all the tested bacterial strains. Furthermore, from the antioxidant screening results, it has been observed that compounds 6c, 6e, and 6g manifested profound antioxidant potential (IC50 < 7.68 mu M) in comparison to the standard antioxidant ascorbic acid.

  DOI：

  10.1007/s00044-014-0938-8
• 作为产物：
  描述：

  2,4-二羟基苯乙酮 、 邻氯苯胺 在 盐酸 、 sodium nitrite 作用下， 生成
  参考文献：
  名称：

  Antibacterial and free radical scavenging potential of synthesized 7-hydroxy-2-aryl-6-aryldiazenyl-4H-chromen-4-ones

  摘要：

  A series of 7-hydroxy-2-aryl-6-aryldiazenyl-4H-chromen-4-one derivatives (6a-m) was synthesized in quantitative yields and their structures were corroborated on the basis of FT-IR, H-1, C-13 NMR, ESI-MS, and elemental analysis data. The synthesized compounds were screened for in vitro antibacterial activities against a representative panel of Gram-positive and Gram-negative bacteria, as well as to evaluate their antioxidant potential using DPPH assay method. Bio-evaluation studies revealed that compounds 6c, 6d, 6e, 6j, and 6l exhibited moderate to good antibacterial activity against all the tested bacterial strains. Furthermore, from the antioxidant screening results, it has been observed that compounds 6c, 6e, and 6g manifested profound antioxidant potential (IC50 < 7.68 mu M) in comparison to the standard antioxidant ascorbic acid.

  DOI：

  10.1007/s00044-014-0938-8